ID   W7J0I5_9PSEU            Unreviewed;       657 AA.
AC   W7J0I5; A0A8E2X771;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=2,4-dienoyl-CoA reductase {ECO:0000313|EMBL:EWC59619.1, ECO:0000313|EMBL:PWW67177.1};
DE            EC=1.3.1.34 {ECO:0000313|EMBL:EWC59619.1};
GN   ORFNames=DFQ13_101695 {ECO:0000313|EMBL:PWW67177.1}, UO65_5087
GN   {ECO:0000313|EMBL:EWC59619.1};
OS   Actinokineospora spheciospongiae.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Actinokineospora.
OX   NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC59619.1, ECO:0000313|Proteomes:UP000019277};
RN   [1] {ECO:0000313|EMBL:EWC59619.1, ECO:0000313|Proteomes:UP000019277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EG49 {ECO:0000313|EMBL:EWC59619.1,
RC   ECO:0000313|Proteomes:UP000019277};
RX   PubMed=24604655;
RA   Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA   Hentschel U.;
RT   "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT   Bacterium Actinokineospora sp. Strain EG49.";
RL   Genome Announc. 2:e00160-14(2014).
RN   [2] {ECO:0000313|EMBL:PWW67177.1, ECO:0000313|Proteomes:UP000247287}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8578 {ECO:0000313|EMBL:PWW67177.1,
RC   ECO:0000313|Proteomes:UP000247287};
RA   Whitman W.;
RT   "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT   soil and plant-associated and newly described type strains.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EWC59619.1}.
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DR   EMBL; AYXG01000196; EWC59619.1; -; Genomic_DNA.
DR   EMBL; QHCP01000001; PWW67177.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7J0I5; -.
DR   STRING; 909613.UO65_5087; -.
DR   PATRIC; fig|909613.9.peg.5083; -.
DR   eggNOG; COG0446; Bacteria.
DR   eggNOG; COG1902; Bacteria.
DR   OrthoDB; 3169239at2; -.
DR   Proteomes; UP000019277; Unassembled WGS sequence.
DR   Proteomes; UP000247287; Unassembled WGS sequence.
DR   GO; GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   PANTHER; PTHR42917; 2,4-DIENOYL-COA REDUCTASE; 1.
DR   PANTHER; PTHR42917:SF2; 2,4-DIENOYL-COA REDUCTASE [(2E)-ENOYL-COA-PRODUCING]; 1.
DR   Pfam; PF12831; FAD_oxidored; 1.
DR   Pfam; PF00724; Oxidored_FMN; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:EWC59619.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019277}.
FT   DOMAIN          2..331
FT                   /note="NADH:flavin oxidoreductase/NADH oxidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00724"
SQ   SEQUENCE   657 AA;  68404 MW;  03C7C08E0249A8EA CRC64;
     MLLDPVRVGR LSLRNRVVVP AHTTNFAVDG LFSARHVAYH RTRAAGGVGL IVTEGMRVHP
     TSLGRTTTVA AFDDRIVPAL AGLADAVHAE GAKLAAQLLH VGRQAGGHHV LTAPWGASDR
     PWSGTAATPH RMTTAEIAEV VAGFGAAAAR VKASGVDAVE VHLGHGHLLQ QFLSPATNDR
     DDEYGGDPDR RLRLAREVLT AVRAATDLPL LLRISGDEFL PGGLGLPEML DAVGALLAEF
     PVDVLHVSHS AYVGSVSVAT QMADMTHPPM AFRHLPRAFK DAFPGTAVLA VCRVDTLDNA
     ERMVADGDAD LVALARPHIA APDLVARHRD RRAGRDCIAC NQGCAGRLEL GLPIGCVVNP
     EVGLEREWAA LRTAAADGPR RRVLVVGGGP AGMEAALAAA GVGHRVTLVD AASRLGGALT
     LAAVLRSGYR LYVDQLAAAV RASGAEVRLN TTADPDLLAE GWDHVVLATG AVERPEPGDV
     DFPALALRAV VEDPARAGGH AVLVDTEGST TGLALAELLL DRGSRVTLVT DRPALAWRVS
     LYTRPALVER LRGRDFSALL MRSPVRVTEG SMILADPLSG RTQAVDGVSS VVFLRPPTAL
     ADLAGPLRDL GVGHTVVGDA HAPRSALEAA FDGRLAGLAA TGGAQTPAAA AALRGRL
//