ID W7J7U4_9PSEU Unreviewed; 326 AA.
AC W7J7U4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Arogenate dehydrogenase {ECO:0000313|EMBL:EWC62109.1};
DE EC=1.3.1.43 {ECO:0000313|EMBL:EWC62109.1};
GN ORFNames=UO65_2623 {ECO:0000313|EMBL:EWC62109.1};
OS Actinokineospora spheciospongiae.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinokineospora.
OX NCBI_TaxID=909613 {ECO:0000313|EMBL:EWC62109.1, ECO:0000313|Proteomes:UP000019277};
RN [1] {ECO:0000313|EMBL:EWC62109.1, ECO:0000313|Proteomes:UP000019277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EG49 {ECO:0000313|EMBL:EWC62109.1,
RC ECO:0000313|Proteomes:UP000019277};
RX PubMed=24604655;
RA Harjes J., Ryu T., Abdelmohsen U.R., Moitinho-Silva L., Horn H., Ravasi T.,
RA Hentschel U.;
RT "Draft Genome Sequence of the Antitrypanosomally Active Sponge-Associated
RT Bacterium Actinokineospora sp. Strain EG49.";
RL Genome Announc. 2:e00160-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWC62109.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AYXG01000089; EWC62109.1; -; Genomic_DNA.
DR AlphaFoldDB; W7J7U4; -.
DR STRING; 909613.UO65_2623; -.
DR PATRIC; fig|909613.9.peg.2629; -.
DR eggNOG; COG0287; Bacteria.
DR OrthoDB; 9802008at2; -.
DR Proteomes; UP000019277; Unassembled WGS sequence.
DR GO; GO:0047794; F:cyclohexadienyl dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR046826; PDH_N.
DR InterPro; IPR003099; Prephen_DH.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR Pfam; PF02153; PDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EWC62109.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019277}.
FT DOMAIN 2..295
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 326 AA; 32554 MW; A208E6313DF0C441 CRC64;
MRSVCVIGLG LIGGSVLRAV SAAGREAWGA TGSALDAEAA RAEGHAVELS VEEALRRAAA
ADALVVLAVP LPALDGVLRK VGELAPGCLL TDVVSVKAPV ADAVARYAPS ARFVGGHPMA
GRSVSGWSAG SARLFQDAAW VVVADEDTDP AVWREVAELA LDCGAHVVPT TTSEHDAAVA
RISHLPHVLA AVLASCGADG GPLALALAAG SFGDGTRVAA TRPELVLAMC EGNRPALLAA
VDDALGKLGA ARGALASTGA LRATVTAGHA GRAALEAQRA AGRVHLVVDL AGEDALEELR
GLGTQGGRIT GFEGTAVKAE LPVLAE
//
