ID W7JBY9_PLAFA Unreviewed; 1275 AA.
AC W7JBY9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=18S rRNA cytosine acetyltransferase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=C923_02984 {ECO:0000313|EMBL:EWC76355.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC76355.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC76355.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC76355.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR EMBL; KE124586; EWC76355.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JBY9; -.
DR EnsemblProtists; EWC76355; EWC76355; C923_02984.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11040; -; 1.
DR Gene3D; 3.40.630.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_03211; RNA_acetyltr_Nat10; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR007807; Helicase_dom.
DR InterPro; IPR033688; NAT10.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032672; TmcA/NAT10/Kre33.
DR InterPro; IPR013562; TmcA_N.
DR InterPro; IPR027992; tRNA_bind_dom.
DR PANTHER; PTHR10925; N-ACETYLTRANSFERASE 10; 1.
DR PANTHER; PTHR10925:SF5; RNA CYTIDINE ACETYLTRANSFERASE; 1.
DR Pfam; PF13718; GNAT_acetyltr_2; 2.
DR Pfam; PF05127; Helicase_RecD; 1.
DR Pfam; PF08351; TmcA_N; 1.
DR Pfam; PF13725; tRNA_bind_2; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 8..199
FT /note="tRNA(Met) cytidine acetyltransferase TmcA N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08351"
FT DOMAIN 431..630
FT /note="Helicase"
FT /evidence="ECO:0000259|Pfam:PF05127"
FT DOMAIN 670..746
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13718"
FT DOMAIN 800..978
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13718"
FT DOMAIN 1074..1241
FT /note="Possible tRNA binding"
FT /evidence="ECO:0000259|Pfam:PF13725"
FT REGION 238..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1275
FT /evidence="ECO:0000313|EMBL:EWC76355.1"
SQ SEQUENCE 1275 AA; 150108 MW; E48E1E40452ACCB5 CRC64;
MKKKVDNRIK ILIENNIAVG QRSMFFVVGD EGKNVVVNFY FLLNRLINRT HNILWCYKKK
LDFSTSKKKR YREMKKKIKK GTFDQTIDNN FDMFLKNADI RFCFYKESKK VLGKTYSICI
LQDFSYITPN ILCRCLETVI GGGLIIFLIN KQNELKDLYN LTLNYHKKYT MNGICNVYNN
YIHRFFLSLN KCENAMFIDD EMNILPLNEN YLKIKKITSK GSDGNGIGNN VTKLKHMEVQ
KEGEQSGSNI NNNDDDDNDD NDNYSNSNNY SNSNSNNYSH TKSATLGGFL CPDKNLLQEK
LKFLESICEE NEKKKEEEKI FLYSSKFSRN DTCTKINKNG DIHSSDNKYT RDTYETYDSV
TNTSTTANTY NNYISKKTKK KDVYSFLDRN IMNLLNICLS LDQLEVLLNM CKILRNDEEK
KKNIKEVLFN LLANRGRGKS ATLGLLLSLS IYFNYSNIII CSGNNEGVQT IYDFLDKGLH
ILGFNEFKDY EKIYDMGKIK EIVIFKNMKY LKQRIRFFDI IEEDILNSEL MIIDEAACIP
IDILKKKIKG EITILSTTLN GYEGTGKTFT FKLLKQLKKK FITQLSYEEF KNMNFLYFDK
AYIDLTLTNP IRYSYNDQVE KWLNDFLCLN CNEPTNIKDN ICSPSNCELY FVNKNIFKNY
NRTSEILLKK IMTLFITSHY KNTPNDIIMI LDSQQHHLFI LINKNNNHYN NNNILEDQID
ELDIYGVLHC AIDGIINNGN VKKTVKLEDI IHLVKNNNTQ KENPTLDTKE INDSNDQKLE
KKENINQINS DNHKELLINE YEGNLIPYII SDYFNYYFYN YIGIRIVRIS IHPSMQNLNY
GSEFLKKVCN YYNEYNSKQR HDNNTKQKIK INNNDSNNCG DSNNCGDSNN CGDSNNCDDS
NNCDDNVKYS ENIILFNCNG KNIYFDKKLK QIDYIGTCFG LTKGLLIFWQ KNKFIPVFLK
QQKNEITGEF SVLMLKHLNE DLKHIIANFY TDFVRSVTKL LPYSFKYMES FIVFNLLHNN
NYSIPLKQDD APTIVKDHNN TDHTYNHNGH IKNNLHNNHF YYDNYEDQHL SFYNNNLINQ
QTIFYFFHTN DICRLKRFVL EGRNFYEILY LLSTIANLIL FKKVKIDLSF LEYTILYAVA
FQKKTPKEIS DEIKINVNQT NAIFRKIIHR FYNYIKDIME KQIEKEVNAE LNEKLKVKKK
RSLNIELPSE EYKDELERNS LIVKKKLKKE KLSLMKEFNL EGDIKRKEIN IKTNDNLEIK
KKKKKKKKKK TRDQL
//
