ID W7JF70_PLAFA Unreviewed; 1107 AA.
AC W7JF70;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|PROSITE:PS51686};
GN ORFNames=C923_01721 {ECO:0000313|EMBL:EWC77610.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC77610.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC77610.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC77610.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
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DR EMBL; KE124487; EWC77610.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JF70; -.
DR EnsemblProtists; EWC77610; EWC77610; C923_01721.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22808; NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22808:SF1; RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 424..606
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT COILED 1000..1027
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 485
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 432
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 1107 AA; 131525 MW; 2DFF5F6A37A7C9E8 CRC64;
MENDKQSNYY DNEKALEKNE SFFNYYINQK ILKSCEIDNF MEIINKELPI TFRVLNNNKY
SNFIHENIKK QLESICKDKY SIIKLNEEDH MYEIHLTRSE IKKEESYKNL YNYLINLNES
GFIFRQELVS MLPVLFLRLK ENFFVLDICA APGSKTAQIL DYMHTINRRK IKNILIEKFL
KKNMQTLYKN LYPWNNVNDE NCDNLYDSFE LDSYKINGFI KQEEKNDTNK IIMNAQNIMN
SQDVLLYENN INVQNVMTSQ EKTNNVDNLY FDDNMKNDCF KNENITNEYK KDEYKENIYK
TFYNILENNN YDDPFFEYIL NVDNNLYNDY KKLISNNNPD GVVVANDSNF KRCCMLFHRL
KNIHSDCLVV TNNNAVTFPY IYIKRENSNL ENNDHHNNNN NNNNNKLSND SNILQNENSI
FVKKNFDSIL CDVPCSGDGT LRKDRNVWIN WNPNNAYNLF QMQVNILKRS IELTKENGYI
VYSTCSLNPI ENEAVICEIF NSVENLDCLK LINFQNELLT KLNYEKAVKQ WKVVMDDIWF
DTYEQYCSYL QNKESGKYKK IYEKIQEGMF PPCEEFINSI NLNYAKRFFP HHYNAGGFFI
AVIQKGENFQ WKSNMKKENK SKMYVDQNER IAYEREEYRR KYKNKKKYNR KIKNNKNNKM
DHVNKIKNVN GANEDEDQID DESKSENIIK SENIIKSENI IKSENIIKSE NIIKSENILN
ENILNENILN ESILKSENIL KSENILKNDI IQKSNDLISH INKKSEELLN DYINNIDDNN
NNVPNGGEEE NVPNKRSNIL DFEYKHGYRI KINNEKLVKQ QEYVSLSYYE KLICVNNFLE
KIKNYFNLNM NFLTIKNNLY IHLKDNGNTH KLSVDERINS NVKKIYLVSN SAKEILESYT
KMKLKIITAG ITVIQVDKNK KNTYENYYRI NYSGCLNFIP FFQDIDNFFK NKKYREQIIQ
NYFCTVYENK ERQFNFDKYM NQLIDERKKT NLSKLDSNKN KAQKILTSEL KNEKDNIENN
MSEENDETLN GYIKNNINVK YNITTCDALD NAMDTQNGNI KNDNIKNDNI KNDNIKNHNI
TNDNIKNDNI TNDNCTNNNI TNNMPFF
//
