ID W7JFH4_PLAFA Unreviewed; 2292 AA.
AC W7JFH4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Helicase ATP-binding domain-containing protein {ECO:0000259|SMART:SM00487};
GN ORFNames=C923_01709 {ECO:0000313|EMBL:EWC77632.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC77632.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC77632.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC77632.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
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DR EMBL; KE124486; EWC77632.1; -; Genomic_DNA.
DR EnsemblProtists; EWC77632; EWC77632; C923_01709.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697}.
FT DOMAIN 1782..2001
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT REGION 150..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1699..1726
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2292 AA; 264137 MW; DE46A92E127971A5 CRC64;
MFLRNFSYTL ITYRYMYIFS LINILKTTSV IIKTRHKLNH INNSRGIKSL NINSNNLFFF
LRSKIRKTQN YILNNNINKK NYNALFYKLN NKEKKMNNKF SKSLNMNNST NKNDHLMNDN
IASFNKNTDI KNPRSFNQNR NITYSKQFSQ NNNYSSTHNN NSVSKGKASG SYINSGNVNV
SSNQYVNSNN NNNINSNNIN SSSSNNNNNN NSSNNNSNNK FSNNFAGTYS TFIQNREMNK
NNEGPNSSFN ETKLNNSSNF HINNKEKKNY NNILSNNNNN NINNKNNDGD NINMLHINEN
SGMYGTKSNY NNKDYLLISN NMKDKNMYLN NNTLTNTNNL DNSLKINNYN NKHNDKNINT
RSSKILEDPN SYNNALKNND SRYNYYNENF TNNIKNVNNA NTGVNSLKNM KNPFNMNKKY
MSHYNNNDNN NNNNNNNNNN NNNNSHNNNY NNQPHSNNYY YNNKSNDNLN NNKTSSSSYA
PNFKRETSDD ISNNNINYNN TNYNNTNYNN NNYNNNNYNN NNYNKIKDSN NNSNNNMIIM
TNEMNSIDLH KNINILTMES SNCNKIDMNN NILSTNETIH NVGNKHGNND INKTNHHNNT
TTTSSSSSNN NMLKLNNIMK NKDINKNDNI ESNHQYNAHD ILYDNSRGAM VDTMTPGYNR
SSRSNKLSMQ NYNHINHNMD SSKNMISPND RSSINKGDIT MNNNENNNNN NNMGISRSSS
NMFTKHNSFH NNNNNDLNQI NNFGIKKNEY YGNFSTSANA KNVNNLINKI EDNKNNNNIN
NNGGHLDLDS DAFCYYDFNE FLNYMYKDEN ILTLFYIRKN YLKAESKEEF INENDKIKYS
IIWSFTNDEK IVVYGTHNTK KLSKKVCVKK ILLKLKNISL LELDQMTKWM INSLNVILKV
ENKNLENKFN NNVYSCNIEW KINNKLYQAS AQHEHEKIAE LVATQRLYMI LYDVKEQLIR
ENDFSKMSDD NKRFINSYDN TTIINNNTSN NNNNINNTGS NNNTLYNKYM SSNSKNFDDG
NMLNQNKFNK NQGANKNFNE LMYNNNNHTA SSNNNNNNNV LSYQENKNIK YGDASNDHML
NRNNNMNMNN YMNNVCYNNN NNMNNILTSA TDIHHNNNNV NNMNNMNNMN NMNNMNNMNN
MNNMNNMNNM NNVNKNVGHM GATQGTIMNN NMFLNANNAK YMNENMNLLN NAQHGGIQQV
GAQQIGAQPI GIQEVGTQPE QVADPNDLIE YCLTKQDASS IQMLRNNIAS RYKIQQSEVF
EQVFNLYKCT LDWEWKNGKN TCKAKSVGYG STKSLAKCEA AYDMLVKNNL IEYISSTDRK
NAQFIRDLIS KDLNKALNMA IQFIMQYSSN AWSIFVVYLL RELLIDGNYD PINRLLNTIV
EVSREGRMEV EKMEKDMNQN VNNVNHINNM NNLNNMNNLN NVNDESINTA SATMFHNNKV
DENNDNNNNN SSQFFNPYIQ NKNLTDNNYV HKLVSIELWE KLIDECVVIL NDKLCFNCIS
LLQQVELDYS IFISKCAHDY YKKYRIMLAL ELQANLAQSI QEKKNFEYLH ENKSLLLKLK
SITMPVLSCT CTLTNEEKEW MKSTQMREDD IVLLKPCDTL LKDEDAWSNS LIGSITSTKS
DNTVYNINIR IFSAENTKKA NVKYNKYRLY LLLNIVTHER MLQALRSITF ISSIPTQYQS
PYVFTPEIRF LLLHSYNKYS KYIAQNGKLN EEIANYEKIK MDFQNNESLK NNTMSDDILN
DYSKEAKNPY EDLLNESINK QIGNSQVEDI DKYLIESINL PTNLPLNDSQ KLACLSALTR
RLTLVQGPPG TGKTHVACAI IDSWHKQNSN KKILAVADSN VAANNLVEGL KKRNIQAVRV
GAGSDSDFHE EAIMEFHRYK DLLKLRKNNM QKEAKVMKAL LFLEAVKKYN VVIATCVGSG
HEIFDNEKFE RVIIDECAQS IEPSNLIPLG HYCNNLVLIG DHKQLPPTII SPDAIKLGLD
KSLLERFVMA KIAPVHLLNT QRRMHLSICV FPNFHFYDNK LKTANVTEEN RPIIKGFLWP
NPKCRLAFID VSIGKPGSKF ENAYGTSKFN LYEIEPLITV LKSIINEGCV SVDEIGILTA
YDAQKMKLKK AVQDAFSYEA SHRIEIDSID GFQGKEKDLI LFSAVRSNAN NELGFLRDAR
RLNVMLTRAK RGVILFGDQF TLANDPANWL PWLKWISSKR AIVHVTKLND HLENTDYSLL
DKLNKINKAV NLKNINVSDN YYFYGNDTGF SNDYDQNYFT NNDNINMDDV DNKDGAADQQ
VEEIVENWED LL
//
