ID   W7JLU4_PLAFA            Unreviewed;      1172 AA.
AC   W7JLU4;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Diphosphate-fructose-6-phosphate 1-phosphotransferase {ECO:0000313|EMBL:EWC75859.1};
GN   ORFNames=C923_03476 {ECO:0000313|EMBL:EWC75859.1};
OS   Plasmodium falciparum UGT5.1.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC75859.1, ECO:0000313|Proteomes:UP000030697};
RN   [1] {ECO:0000313|EMBL:EWC75859.1, ECO:0000313|Proteomes:UP000030697}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC75859.1,
RC   ECO:0000313|Proteomes:UP000030697};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KE124620; EWC75859.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7JLU4; -.
DR   EnsemblProtists; EWC75859; EWC75859; C923_03476.
DR   UniPathway; UPA00109; UER00182.
DR   Proteomes; UP000030697; Unassembled WGS sequence.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.450; -; 3.
DR   Gene3D; 3.40.50.460; Phosphofructokinase domain; 1.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   InterPro; IPR035966; PKF_sf.
DR   PANTHER; PTHR43650; PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE; 1.
DR   PANTHER; PTHR43650:SF1; PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT BETA 1; 1.
DR   Pfam; PF00365; PFK; 2.
DR   SUPFAM; SSF53784; Phosphofructokinase; 2.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030697};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EWC75859.1}.
FT   DOMAIN          86..243
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   DOMAIN          708..975
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   REGION          396..490
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..453
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1172 AA;  137047 MW;  BA697A14ACC7F1FB CRC64;
     MEDNNNICEI LKNYVQEDKI YKPYNIIDNN KTCVSNENKS NNNIPYDNIQ SYNMSYDNIS
     TYDFTYDNIS DISDEEINKK YPKKNKSFVK TSIVSAPTCV YNEMKNKYIE CSLGFDTTIF
     SYCQYISYLI THIQTYLQGY HFIKVMGNSS SHIALECFLQ TKVNIILVTE EIKKNNLTLD
     QIIQFIVDVI QNRYKKYHKN YGIVIIPDGI LKKITQFKKL VTSIIHIKTK FIENKINILT
     DLQNILSKHL IKEQQEFFKT LPDFFQIQLL EEICSQQFHY ARLSTELLLT HLVKKKLEER
     QINDLEFHTH SYGKEVTCSL PTNFDCAYSY ILGFSCVEML QHKYNGYMCV IKKLKNLLLN
     VNDIEILGIP LCHIMKIKKK NKNVAQINIV EQVKSAGEKK KKIEEKDNPQ EIKENGKINK
     AEKPTKKNKT EKKDKVTKKD KTSKKDKNNT TDRVKKSSSN IQNDNVNKKD DALTNDLCEP
     TDSTTNNQNK NALVIRNDPF EEFFIKRTKV NLKDDAYFIK YKKYRYMYLY EDHYRVLTGI
     QYEHNFCIDY DDKSLKFRNK LNSTLSSNDY ITIKPNNIFS KINFTISGLT KEYFNKKEHN
     EEKSSMTQNN ILQNGVILQN NNTYKFNYCK HSSMLSEIEK MLTASAIKFN TILIRHNTRI
     TYINNNFFNK LYTISFIHIP KIKDFYILQD NQFHLKQNYR NVTCPKNVGV VLLSHCTPGT
     NNILVGLHQR LSINNFKLIG FIKGLKGLLN NDICLINDNN LKTSINIGGF PLLGVHIQYE
     KKTNDDQILH IHDLIKENNI SKIIKSCKNN NITNLVFIGD EKVITLMNIL NDIFINKDVN
     IKIVSIPISL YNSFDKNLIE CSIGYHSMVR HISDIISNVQ SNCLNINTYY YFIKIHTNIS
     SSLILSVQLQ THCNICYIGE SLNNQLTSLH TVIENISLII IERINRMKYY GVILFSSNLI
     YYINDFHELC KDVDENIKNV QEIDEIVKND ILPERFQKIL KKESVDLLNL LTESMKDKLL
     RKEKRENEDI DSNFEVMLIN EIKKYIQNLM EKSKQNKELY CYKKHMNTIS SPINVKNIKV
     YSDIDYILHF QTLIKVIDRE INCFFPTHFD NSLAFSHGLL AGIAVENDLL NYVTSIKHLN
     LNKQNWSSSL YPGIYFINNK DDKGHFNEVL KK
//