ID W7JLX4_PLAFO Unreviewed; 515 AA.
AC W7JLX4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Protein disulfide isomerase {ECO:0000313|EMBL:KAF4330490.1};
GN ORFNames=CK202_4082 {ECO:0000313|EMBL:PKC45088.1}, CYL21_0861
GN {ECO:0000313|EMBL:KAF4330490.1}, PFNF54_05559
GN {ECO:0000313|EMBL:EWC85893.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC85893.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC85893.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC85893.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC45088.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC45088.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4330490.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4330490.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000256|ARBA:ARBA00006347}.
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DR EMBL; KE123882; EWC85893.1; -; Genomic_DNA.
DR EMBL; QFXU01000008; KAF4330490.1; -; Genomic_DNA.
DR EMBL; NYMT01000014; PKC45088.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JLX4; -.
DR SMR; W7JLX4; -.
DR EnsemblProtists; EWC85893; EWC85893; PFNF54_05559.
DR VEuPathDB; PlasmoDB:PfNF54_090024500; -.
DR OMA; ALFCNNK; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR18929; PROTEIN DISULFIDE ISOMERASE; 1.
DR PANTHER; PTHR18929:SF243; THIOREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR SUPFAM; SSF52833; Thioredoxin-like; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:KAF4330490.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 68..135
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|Pfam:PF00085"
FT DOMAIN 401..484
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|Pfam:PF00085"
SQ SEQUENCE 515 AA; 61001 MW; 7F5ADD340829C94B CRC64;
MKHFCFNNIL YIFIIYIIFL LHLNNIILCE GAIWEGISKD EIRNVKHLTH EVELQIYSQH
TQNCMALFCN EKESKCKNVY KEFVKASNEL IDNDVVFVYV DTISLAKTAD NFEIKNIPKI
LTFKDFDPEK GYTFNRKYTK ENILEWFKLL PEPSIEIMEK NNVEKYVEMH KKKGYASIIA
FCIRGSDNAN KFVHFGETQK LPNLAVGLIY VENDEDVKIE IFNGPGSTIP KENFKYKDTY
VPYNGIWTSD SIYQFAENYM KQFPVIINYH RKSLPPLNGD IYFYIFNRFG EYSDTLYVEL
YDLIMKHNQI KFVFPRKDEV LEHFNIENNM SLISIMDYNN ASFVTLSQML RPKKYAKIMD
ENITVSHVES FLDEFLKNNL AVYRKSEKPI KRREKQKYQI LCSNDFESYV MDPEKLVLIF
YHVQGCKECK PLFTFWDTVA NYFHLENKYK DVLVATMDAK LNDMIDESVD YYPSLALYPK
GENKLKRKHI LLFPMKLDTL IDVVDEYLED LDQDL
//
