ID W7JNH3_PLAFO Unreviewed; 439 AA.
AC W7JNH3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|RuleBase:RU365059};
GN ORFNames=CK202_4441 {ECO:0000313|EMBL:PKC44625.1}, CYL21_5639
GN {ECO:0000313|EMBL:KAF4326656.1}, PFNF54_04760
GN {ECO:0000313|EMBL:EWC86428.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC86428.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC86428.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC86428.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC44625.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC44625.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4326656.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4326656.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE123867; EWC86428.1; -; Genomic_DNA.
DR EMBL; QFXU01000024; KAF4326656.1; -; Genomic_DNA.
DR EMBL; NYMT01000015; PKC44625.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JNH3; -.
DR SMR; W7JNH3; -.
DR EnsemblProtists; EWC86428; EWC86428; PFNF54_04760.
DR VEuPathDB; PlasmoDB:PfNF54_130054500; -.
DR OMA; QMLGPNC; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT REGION 318..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 52158 MW; C5EDDEA58D40C4F8 CRC64;
MKYGQVVVGP AGSGKSNYCK MMKEFMKIKK RNCYVVNLDS ACEEYYYERK KKPINTTYNI
EKELNDYYDT IYDIDIRNYV EVNNLMEEQN LGPNCALLRS VEILYENSYL LEDELNNYDD
DDNYFIIDTP GQIELYTHTD YFKKILNIFS EQNIRLVIVF LIDISFISSN TKLLSAYLTS
LSTMINFELP HINILTKCDL LISKNYYHEF NNFKNRNNFF YQKQLYKKIN QKLIYYKKQG
TYQKNNAEEN DLYNNNHNLR HMKNNYHNLN LTNQEHNQNN DEDDKSFLEE IEFINNTKSF
KDEFVLWSDV ENTSVSSYSS FNSNQKENNN SIYNSSDEQK SVISDECEES IYKKNYEKLN
DILSLDPHDI IITANKCMSK KYYKLNNAFA NIIEDFNLVS FLPLNIYDDD NVDFIINSID
MIIQYGEDKD VNDNYDMFS
//
