ID W7JQ79_PLAFA Unreviewed; 867 AA.
AC W7JQ79;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=ATP-dependent helicase HrpA {ECO:0008006|Google:ProtNLM};
GN ORFNames=C923_02266 {ECO:0000313|EMBL:EWC77069.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC77069.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC77069.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC77069.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE124534; EWC77069.1; -; Genomic_DNA.
DR AlphaFoldDB; W7JQ79; -.
DR EnsemblProtists; EWC77069; EWC77069; C923_02266.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF234; ATP-DEPENDENT RNA HELICASE DHX40-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697}.
FT DOMAIN 14..198
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 303..528
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 236..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 101809 MW; DBAFA31F6DA1E2C9 CRC64;
MRELPILKYK HEIKKLIKKN NLIIIKGETG CGKTTQVPQI INEIFFDKKE KKYDNIKHKN
DEKKKRKEKK KMLISLPRRV ATITVAERVS KEMKRGDIGN YVGYTIRFKN VCSDKTRIKF
VTDGILIREI MNDPLLKKYK FLILDEIHER SIRTDVLLGY TKILLQKRKK IKIILMSATF
DINIFNQFFN NPPIITIPHK LHKITIYYPR RNIEDYILSV VSTILQIHFG NTSYSSEFEN
DDDHRENKPN ELNELNKSNE QNELNESNEV NKEHDSYESN KTHDINEIDE QNNLQTDNIS
MNNINEDIKK TEDKSLGDIL VFLPGQEEIE MVNIMLKEKL KIIYKGNLLN KLMKERNNYN
NQNDFQNKIN NKFNTDDHIL NEICFHFGKT EIMPDKIYNM KILQLYSSLP NKKQKVIFEP
VPPNTRKVIL STNIAETSVT IPNIKYVIDS GKVKIKYFDV NRGSNVLRVT QISKDSAIQR
SGRAGREAPG QVYRIYTKEE YENMNPFLIP EIFRSDLTQI YLELKAMNIN NPLEFNFPEN
PRKELFVHSA KMLFKINAID MNNNLTDLGK KLCLFPLNPI YANILLCSIE FNCIDEIATI
VALLNCDSIF LNYNFYEDLD TLNNDSLDKK KNNNEQKKIV HKNSVEDSKE NINKLENYDK
KKGKNNNLEP YDDDHDDNDN DSNNNDDDMG EKKMNDKNKL INVARRKLIH PDGDHLTLLH
IFYLWQEADI KEKKHFCNIY ALNNEILQQV EKIKIQLLEI MKNKMKIEIP KKLHMHKWDQ
ILICLCKACF FNIAKSTSNT NVYINLVNKT KIRIHPSSTL FNSYIKPTFI FYSDIVQTKR
LYARIVTKIE ADWLLKYVSA KFQVAKS
//
