ID W7JTZ5_PLAFA Unreviewed; 2417 AA.
AC W7JTZ5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=histidinol-phosphate transaminase {ECO:0000256|ARBA:ARBA00012748};
DE EC=2.6.1.9 {ECO:0000256|ARBA:ARBA00012748};
GN ORFNames=C923_00754 {ECO:0000313|EMBL:EWC78568.1};
OS Plasmodium falciparum UGT5.1.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1237627 {ECO:0000313|EMBL:EWC78568.1, ECO:0000313|Proteomes:UP000030697};
RN [1] {ECO:0000313|EMBL:EWC78568.1, ECO:0000313|Proteomes:UP000030697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UGT5.1 {ECO:0000313|EMBL:EWC78568.1,
RC ECO:0000313|Proteomes:UP000030697};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum UGT5.1.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC ChEBI:CHEBI:57980; EC=2.6.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001045};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; KE124425; EWC78568.1; -; Genomic_DNA.
DR EnsemblProtists; EWC78568; EWC78568; C923_00754.
DR Proteomes; UP000030697; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd00615; Orn_deC_like; 1.
DR Gene3D; 3.90.105.10; Molybdopterin biosynthesis moea protein, domain 2; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
DR InterPro; IPR036633; Prn/Lys/Arg_de-COase_C_sf.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR PANTHER; PTHR42885:SF2; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; 1.
DR PANTHER; PTHR42885; HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED; 1.
DR Pfam; PF01276; OKR_DC_1; 2.
DR SUPFAM; SSF55904; Ornithine decarboxylase C-terminal domain; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000030697}.
FT DOMAIN 585..810
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT DOMAIN 859..948
FT /note="Orn/Lys/Arg decarboxylases family 1 pyridoxal-P
FT attachment site"
FT /evidence="ECO:0000259|Pfam:PF01276"
FT REGION 378..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1031
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2417 AA; 280970 MW; 57B9CFF68AAA210F CRC64;
MKLSNDPNFQ IDEDSLHMNN IDQNKIEEDV IPDSKAVSDY NVNNQEVQRK SLSLKEDEKM
RINSVGVYKV KREEYKNNMH PRNVQQKNIN QMYKQYKNIN TKVYDENIEY HRKNYEENLY
GSTKYDRIEE LENYININNV TSVCSLRIKL WEALLLYVNN LNVEFIYFII SCLKEIEVYW
GQEATENLHE IINLINDKKY KEVSNKIRET LSSLSVTTGK ITDENPFFYT LIVSSKRDEN
RSNSTNNYSD LTCELNKILQ YEHNRLSNQI NNKTLEYKII EVSNAREALL ACLINPQILS
VVIVDNLNID EERVEEKDIY NYYNDENNSV RNHSVANSYV YNSSIVNNVH MPINKSNMNN
IALNALALNN KDIYMKGMMG TSRHHNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNSG
VNDFRKNKSY NYSNNYINNN MNLNKYNDSN KKNIINNVNN LNNMYNLNNM YNMYNICNIN
YNNDNICHHQ FKEYKFNIAD FVLGYVQLVS APLEKMKKGF NSLVILIKSI AYIRSSVDIF
CVCTSITLDS LQSVNNMIIR IFTTHDDHSD LHESILDGVK KKIKTPFFNA LKAYAERPIG
VFHALAISKG NSVRRSRWIQ SLLDFYGVNL FKAESSATCG GLDSLLDPHG SLKDAQIMAA
RAYSSKYCFF VTNGTSSSNK IVMQALVKPG DIILVDRACH KSHHYGFVLS QAFPCYLDPY
PVSKYGIYGA VPIYVIKKTL LEYRKSNKLH LVRLIILTNC TFDGIVYNVK RVMEECLSIK
PDLIFLFDEA WFAYACFHPI LKFRTAMTVA EKMRSTEQKR IYEKIHKKLL KKFGNVKSLN
DVPEEELLKT RLYPNPNEYK VRVYATQSIH KSLTSLRQGS VILISDDNFE SHAYTPFKEA
YYTHMSTSPN YQILATLDAG RAQMELEGYG LVEKQTEAAF LIRKELSEDP IISKYFRILN
ADDLIPDRLR QCTVSYMKRK HVNNNNNKKK NNGDDDDNDD DNNNDDNNNN DDDNNNDDDN
NNDDDNNNDD DNNNNNDINH DNNHNNHNNV GNQKKYNNSL NSRCSADEDA TGSYIFNNNI
KEIEDNTESA HKIPIEYVDG KLFNVIKYPH EYMSEDNSPN NIHTNLQKSN MKLLNDNNIE
VGRILESSNC FKYSHNVNMC NVLINNSSYR NNSDNKKDGS EKRYVYDEYN ESVKEYSPND
DTNYDATYKG YVNGHVNVNM NNLMNGDNKC DWYDTNDCDD NKNIYCDKAN NIYYYGNNYK
SKEEKRKKAN YGSVNSICCD STYCMDTSDD NLSSNECSSY IDNNNNNNNN NNNINNNSNN
NNSCSGDMKN FLEYFERSWL SEDEFVLDPT RITLFTGYSG IDGDTFKVKW LMDKYGIQIN
KTSINSVLFQ TNIGTTGSSC LFLKSCLSLI SQELDQKKSL FNERDLNQFN ESVYNLVYNY
IDLSVFSAFH PLFKKRYEDK NIFNNEGDLR KAFYLAYEED YVEYILLNNL KDRIRHKEMI
VAASFIIPYP PGFPVLVPGQ IISEEIVNYL SGLSVKEIHG YDENIGFRCF YNFILDYYET
ININDPYSMY QPMDKRLYEQ LKEKYLHSKK DLHDHRLSNL YMYDKETMKM KKVYIHNNGS
YSVDPYGYIS DLNEEEGVII NAQHVNNKKD IFFHNKRENK IHNNNNNNNK KKTHVNNKSD
VMIIIPSEDH LNPHIIHKMS DNNRKIINTK NYNNIINYTS NILNNKQDHA FYNSGSPRTS
VCSNHKNINT NGMFNNLMHK NDERGNNKSM SKHEKNNHSL YLTNGVNTKS HKKMYIESYN
PKGDRELDFQ NKSTMYNNMD DVAYHGKHYY SVKKDIINND TSLKENRYNK NIMSCKTNNN
TGTNSKNERK KKKSFGIHMS LSPNNNHLKG HDTSRYSDST SICEDNINDD NIDDTGHKKM
DAIDGHNIRN KKSDIKEILY NNNDNDIYGN ACDVIACKEN MYINEKDSYS DVVLIKRNNK
INKNDGNYYY HNNFSNNSKH SNVVPILNKG NVLLNNTNVK KNDYCVIQKD NKIMSLNNMN
TKYASSNEYN KKKEEGAYYS DSSKNIHDNL FLKRKENENI EHITKDVMKK PLIGYNKEEI
KKINEFLKIN RRIADEHMGD IQIKLDEEIL ERKEEDMYDN KNDMFNVNIK SNIEDVADNS
PQMNIDKKDI IVLASNNNYC DINNNNNNNN NNNCNYVKKC ETNKCDIYIT KDNLEEIQKT
NMNIKKDVEH DIGEYNFDSV INQSVNNNIN ILIDKYNCNN IKKLNNSNIC ENNNLLSNDN
NYIVNHKVYS SIENTNTLNC NNIKTDNNSN NNNNNMPYKE NKVRGLIICE NDINKNTGRQ
LNTLNNNSYI NNLITNVDDD TFVHREGNFF LQCEFTNSDI NCNMYEMETS LNNICTNLGG
VIIKNNMEYD DCETKHK
//
