ID W7K0K0_PLAFO Unreviewed; 2533 AA.
AC W7K0K0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=P-loop containing nucleoside triphosphate hydrolase {ECO:0000313|EMBL:KAF4326671.1};
GN ORFNames=CK202_4452 {ECO:0000313|EMBL:PKC44636.1}, CYL21_5655
GN {ECO:0000313|EMBL:KAF4326671.1}, PFNF54_04791
GN {ECO:0000313|EMBL:EWC86460.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC86460.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC86460.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC86460.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC44636.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC44636.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4326671.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4326671.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123867; EWC86460.1; -; Genomic_DNA.
DR EMBL; QFXU01000024; KAF4326671.1; -; Genomic_DNA.
DR EMBL; NYMT01000015; PKC44636.1; -; Genomic_DNA.
DR EnsemblProtists; EWC86460; EWC86460; PFNF54_04791.
DR VEuPathDB; PlasmoDB:PfNF54_130057300; -.
DR OMA; CINDYVF; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KAF4326671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 589..794
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 1124..1272
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 1709..1822
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2099..2259
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 2268..2460
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1580..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1587..1611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2533 AA; 304306 MW; 42BB01D2646D26BD CRC64;
MRKTSKSKKR KASDKSSSRK NSSQDTFDTN SSINEKAQDG FNDEPSNLEK AEESTNNSYK
VNNNNINNDD DDDDIKFLIE HVDFQQFCDI KKKGSVPYKN KKNDENINNN NNNNDNMNGD
MEYNNSPLNI IGKTYDYLRR KNFKSVHLKK LENYQYFEKI LWPYYNMYDN FYELNNNSIF
FHSNDELNNK KNVHLKHLLS IVIFLCYKYE EKGKHEIWEQ LIYNKIDEFD KLVYNEKNGL
NRNSTTFDID EKYNLYKEFL IEKFNNLFFN TLKLINYNFV ISEFLSSDLK GNNDQILLDN
LKRYRKKLFK LNFLEKSYIL QFFINIYSSI DKKFLFKLCV DLCNPFIWIY INDTYLNTFL
FKTNEDAKVL YNNILNVMKR KYDNYENYDI LSIYTSNCVV DTQEQEHNIP NHDKKKRKRS
STKINNDIQN EENKFCYDEN VILFINKNAF FYNLINYFLL VLNYVERNNF DELYDTDILS
DTSNDENIFD KMNIFENDDD DDDIYTFDDN KKIGTQLLEK LKIINENITE EENTISYLED
MDILLKCENK INDEKYNKNI NMLINIDLQN KEENFENDYK YVSSEDDIYE YNEYKYNNNN
NNNNEHYKKE EILSLFSKYE KKVKDMNNKE YMYRKNKIQK KDTCTQNNNK YILLFLEKCI
EFFIDLLSQL YSRRILFIFL KYFNVFIYCK ISKLNKDKRQ FKELVKLFKY YMEIYIDNFS
GNPLTYLEIN NEHYKNFESF QIFCYKYYKD HNILKNYYLK SVYVMDKKKE MWENLTKLDH
HVLSFLCQNL NYVINIDTYI DNDESMSEPK KKLSLTSDTD VNMDKNINDN INDNINDNIK
DNIKDNINDY NNNNNNNSCS SRGKKGRKGK NKENEEKVET KRENNEEKNR EQFKCYNENK
YNYLFNHLNI FHEKKKIFYI ILLIENLSFK KNIFEEIEKK CDYPNEMDLF DNILIYSNED
VKTNNEKKKK KKYILYTKPL FKLNLQYLCI NDYIFRIYNL FKLQSYYDIK KNILEYVYET
NPKNKKVNES SILKYVYEID DDGKIDYHNM NEKEYKKNYY NNEETNNYQS SNTIDNVNNM
RKKRKSNNEI EENDIILYND NHIHKNTYNE YQLKSIIIDI NKIENTYFAN ERRMSNKIDS
FKIMNVDDDN KKVTAEIIID LRYKQYERIK NEWNMIRSSD ILFLVSVKNY TNLYKNKLNV
INDNDMKKLL GINYVRGCEV IKYSNIGNDD EDINNEKCTL KKITVYLDYI QYQKDILNNP
DIYESFNLLI RRKQKENNFY YILNNIKTLI LNPDDAIIPH WVHDIFLGYC DNSIKYYDET
LHNAYHPDKD EQNVEDESDS DNNNDEYQTD SNDNNNDNNS DDNNDNNSDD NNNNNDEDET
HSDNNTDNAP LNDHNNSNTS DVLSNVDEAQ SSKSLIKNKI SYNKSLFKFM KTNVDDINYL
NTFLNIGHIL KTTNVGYMCV DLSYMNILND NNFNVHDFLN EYIEPLYLSY VPIKYEHEKD
CMKKNVLEKN IIESLFYHIC VINKYKIDDT SFVSKFVANI DIVYECNNFF VFQFEFKEKK
YFLIFNNFLS KQQNQKNVVQ QFEQNQKEDV STKKKKIKKN NNNDNNNDDK DGNSEANLAN
NLQTNNNKCV TIKDHNKIKN IYHKIIEDSI KYLRIKDGIY RLQNKIYEDP NYPLEGLLIH
TQKKNSTNVK YINNEKKKEI IKKNIYYTER QIECIKSGIY KGITIIEGVP GSGKTSILNK
IINILFNNKK NEKILICTHS NSCLNYIFNL LVKENVIHQK YLCRVGMGEV DSENFINEYD
IMNDKLNKQY NKKDEYMNTY ELNNMYNNYD DENFNFSKYG RINYMLDLRQ KLLNDLNLLS
ESYNNQKIYN CLTANQYYER YVKKRIYLYF QFVYLFKNKF NNEENKMDEF FNLYFSLSAE
DYDIYNLFLC PKIYVQDHED NINGLLWKNY NIEENSNCKK IKCMDLLKDD EPYFYLIHPK
NQLKVLNLSI YNILFPFKKY LNLKLQRISL QMYLENKSKL YEAEKGKYNL QVLDKIVETN
LISDENHNTN GVINVEYDDK NNNNNIINNN NNNNNDNVDS LSDNYGHNVQ NSAHIAKIND
LENNDKNDKN NNILKKNNNT NPYINDDLDE NHFNIQFQQG EDDLYVSKYY LSKLVKNFEH
LKDCRAFEVL RNQRERCTYI IAKLARVIAM TCTHASINRS KIAKLQFYFD NIIIDECTQI
TENDTFLPLL LQENRYYKSK LKRIIFVGDS NQLPPIIKNK YIKDFANYEQ SLYKRFLRLD
LPSIYLNEQG RMRSEICNIY KYFYSKYNIE ISNLECIYKD NFVKSFNPGF TYTYQFIHVP
SEEYSPIPYF YQNLLEAEMT VAIYMYMRLI GYPNDVITIL TTYNGQKELI LDILKKNCMY
NKLIGMPKKV TTVDKYQGKQ NDYIILSLVR SRSIGYMKNI KRLIVAFSRA RFGLYVLGNY
NLYKKAYEFK KPLYFFKKNK LQLSLHINEH YLNTTYRHIE NTSNNSSLII NDLNHFYTII
YSLLNYQLEQ PKK
//
