ID W7K2H6_PLAFO Unreviewed; 758 AA.
AC W7K2H6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 08-NOV-2023, entry version 57.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CK202_2054 {ECO:0000313|EMBL:PKC48611.1}, CYL21_4838
GN {ECO:0000313|EMBL:KAF4327344.1}, PFNF54_03658
GN {ECO:0000313|EMBL:EWC87534.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC87534.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC87534.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC87534.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC48611.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC48611.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4327344.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4327344.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; KE123842; EWC87534.1; -; Genomic_DNA.
DR EMBL; QFXU01000022; KAF4327344.1; -; Genomic_DNA.
DR EMBL; NYMT01000004; PKC48611.1; -; Genomic_DNA.
DR AlphaFoldDB; W7K2H6; -.
DR SMR; W7K2H6; -.
DR EnsemblProtists; EWC87534; EWC87534; PFNF54_03658.
DR VEuPathDB; PlasmoDB:PfNF54_120016600; -.
DR OMA; ITYCKTR; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17756; MCM5; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT DOMAIN 365..570
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 85859 MW; 765255D08DBC604C CRC64;
MIGIQEGRAF FNPTRNPNNR PENNIRIEEN LPSLNEVYNY FQDFLSRYSS NTLKEGNLKR
TLFENVKNNN FTLDLKLDDI YKQQTVFENN EISATPRSER KMKKPENYSA ILARALSERP
LTYLPTIERV CYEVCETANI LNDEDEHLNY IQINLLNTFI RPTPIRGLLA ATQERFVVVP
GIIVQASKPQ HKMRKITLQC RYCDHKMSID VPLWRDKPQL PPYCRYSSTM KSSMGLGNAM
DSQLGCNGVL EPYVILPNEC TFVDIQSLKM QELPEAVPTG DMPRHLQLNV TRYLCEKMIP
GDRVYVHGVL TSYNPNPRPT RADGTNFSYL HVLGFQKYDD MSGNDLNFDV EERNELTLLA
AEHNIHEKIF KSIAPELYGM DEVKKACACL LFGGTRKRIG EETKIRGDIN MLMLGDPSVA
KSQILKFVNR CAPVSVYTSG KGSSAAGLTA AVMRDSQGVF SLEGGAMVLA DGGVVCIDEF
DKMRDDDVVA IHEAMEQQTI SISKAGITTM LNTRCSVIAA ANPSFGSYDD SQDTTYQHDF
KTTILSRFDI IFLLRNKQDV EKDTLLCNHI VALHASKHKS QEGEIPLSKL TRYIQYAKRE
IAPLLSKEAR DSLRNFYVQT RAEYRGDRRS VTKKIPITLR QLESLIRLAE SFAKMELSQF
ATDKHVQMSI DLFSASTAET AKQCLIFETM SPLEQKAVKQ AEDAILGRLG KGQRASRVNL
FRELQLRGFD RSALSKALAI LIKKGELQER GDRSVRRT
//
