ID   W7K4J6_PLAFO            Unreviewed;       294 AA.
AC   W7K4J6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=Biotin--acetyl-CoA-carboxylase {ECO:0000313|EMBL:KAF4327884.1};
DE   SubName: Full=Biotin-[acetyl-CoA-carboxylase] ligase {ECO:0000313|EMBL:EWC88269.1};
GN   ORFNames=CK202_4591 {ECO:0000313|EMBL:PKC43378.1}, CYL21_3620
GN   {ECO:0000313|EMBL:KAF4327884.1}, PFNF54_02875
GN   {ECO:0000313|EMBL:EWC88269.1};
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC88269.1, ECO:0000313|Proteomes:UP000030673};
RN   [1] {ECO:0000313|EMBL:EWC88269.1, ECO:0000313|Proteomes:UP000030673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:EWC88269.1,
RC   ECO:0000313|Proteomes:UP000030673};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF54.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PKC43378.1, ECO:0000313|Proteomes:UP000232684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:PKC43378.1};
RA   Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT   "Plasmodium falciparum NF54 genome assembly.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KAF4327884.1, ECO:0000313|Proteomes:UP000754359}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:KAF4327884.1};
RA   Baumgarten S., Treeck M., Scherf A.;
RT   "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   EMBL; KE123820; EWC88269.1; -; Genomic_DNA.
DR   EMBL; QFXU01000017; KAF4327884.1; -; Genomic_DNA.
DR   EMBL; NYMT01000016; PKC43378.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7K4J6; -.
DR   SMR; W7K4J6; -.
DR   EnsemblProtists; EWC88269; EWC88269; PFNF54_02875.
DR   VEuPathDB; PlasmoDB:PfNF54_100031800; -.
DR   OMA; CQIKWIN; -.
DR   Proteomes; UP000030673; Unassembled WGS sequence.
DR   Proteomes; UP000232684; Unassembled WGS sequence.
DR   Proteomes; UP000754359; Unassembled WGS sequence.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EWC88269.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030673}.
FT   DOMAIN          23..199
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   294 AA;  34805 MW;  699FF8C9284B8CF9 CRC64;
     MEEGRKIFER FYEDINSLHL HFEYLDSTQQ YCIRNMKKFI EDNKLRDDNM IIVSCDKQYH
     GIGTRDTYKN EDRIWLSEEG NVFVTFLFLW NDNLIDKVKL LTQTCTVAIS KTLESFYLVT
     QIKWINDVYV NYKKISGCLI HMYDHMENQK DHNIMNNNNN NKKKICLLVG IGINVNLEDQ
     HNILNNNYTS IKKEYLQDFD TPKLIPTVEQ ITLKLIINVK HAINTLCKEG FTEFLNYIIS
     RLLYKDKKVI INQDNQYIVG YLKGLLHDGS LLLFTEDNKF INVHTGRLHV KDDD
//