ID W7KDD0_PLAFO Unreviewed; 272 AA.
AC W7KDD0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Merozoite surface protein 4 {ECO:0000313|EMBL:KAF4331382.1};
GN ORFNames=CK202_3266 {ECO:0000313|EMBL:PKC46470.1}, CYL21_0201
GN {ECO:0000313|EMBL:KAF4331382.1}, PFNF54_00225
GN {ECO:0000313|EMBL:EWC90980.1};
OS Plasmodium falciparum (isolate NF54).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC90980.1, ECO:0000313|Proteomes:UP000030673};
RN [1] {ECO:0000313|EMBL:EWC90980.1, ECO:0000313|Proteomes:UP000030673}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:EWC90980.1,
RC ECO:0000313|Proteomes:UP000030673};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF54.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PKC46470.1, ECO:0000313|Proteomes:UP000232684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:PKC46470.1};
RA Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT "Plasmodium falciparum NF54 genome assembly.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4331382.1, ECO:0000313|Proteomes:UP000754359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF54 {ECO:0000313|EMBL:KAF4331382.1};
RA Baumgarten S., Treeck M., Scherf A.;
RT "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE123721; EWC90980.1; -; Genomic_DNA.
DR EMBL; QFXU01000003; KAF4331382.1; -; Genomic_DNA.
DR EMBL; NYMT01000009; PKC46470.1; -; Genomic_DNA.
DR AlphaFoldDB; W7KDD0; -.
DR SMR; W7KDD0; -.
DR EnsemblProtists; EWC90980; EWC90980; PFNF54_00225.
DR VEuPathDB; PlasmoDB:PfNF54_020011800; -.
DR OMA; SANKAKC; -.
DR Proteomes; UP000030673; Unassembled WGS sequence.
DR Proteomes; UP000232684; Unassembled WGS sequence.
DR Proteomes; UP000754359; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR Pfam; PF12947; EGF_3; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS01186; EGF_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:KAF4331382.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REGION 50..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 30549 MW; 60F363A4B5553BCD CRC64;
MWIVKFLIVV HFFIICTINF DKLYISYSYN IVPENGRMLN MRILGEEKPN VDGVSTSNTP
GGNESSSASP NLSDAAEKKD EKEASEQGEE SHKKENSQES ANGKDDVKEE KKTNEKKDDG
KTDKVQEKVL EKSPKESQMV DDKKKTEAIP KKVVQPSSSN SGGHVGEEED HNEGEGEHEE
EEEHEEDDDD EDDDTYNKDD LEDEDLCKHN NGGCGDDKLC EYVGNRRVKC KCKEGYKLEG
IECVELLSLA SSSLNLIFNS FITIFVVILL IN
//
