ID   W7KIK6_PLAFO            Unreviewed;       706 AA.
AC   W7KIK6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=DNA (Cytosine-5)-methyltransferase {ECO:0000313|EMBL:KAF4326804.1};
GN   ORFNames=CK202_5347 {ECO:0000313|EMBL:PKC42134.1}, CYL21_5105
GN   {ECO:0000313|EMBL:KAF4326804.1}, PFNF54_01927
GN   {ECO:0000313|EMBL:EWC89362.1};
OS   Plasmodium falciparum (isolate NF54).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5843 {ECO:0000313|EMBL:EWC89362.1, ECO:0000313|Proteomes:UP000030673};
RN   [1] {ECO:0000313|EMBL:EWC89362.1, ECO:0000313|Proteomes:UP000030673}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:EWC89362.1,
RC   ECO:0000313|Proteomes:UP000030673};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF54.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:PKC42134.1, ECO:0000313|Proteomes:UP000232684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:PKC42134.1};
RA   Bryant J.M., Baumgarten S., Scheidig-Benatar C., Scherf A.;
RT   "Plasmodium falciparum NF54 genome assembly.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KAF4326804.1, ECO:0000313|Proteomes:UP000754359}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF54 {ECO:0000313|EMBL:KAF4326804.1};
RA   Baumgarten S., Treeck M., Scherf A.;
RT   "Genome assembly of Plasmodium falciparum NF54 DiCre.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE123780; EWC89362.1; -; Genomic_DNA.
DR   EMBL; QFXU01000023; KAF4326804.1; -; Genomic_DNA.
DR   EMBL; NYMT01000019; PKC42134.1; -; Genomic_DNA.
DR   AlphaFoldDB; W7KIK6; -.
DR   EnsemblProtists; EWC89362; EWC89362; PFNF54_01927.
DR   VEuPathDB; PlasmoDB:PfNF54_070031200; -.
DR   OMA; RLMGYKM; -.
DR   Proteomes; UP000030673; Unassembled WGS sequence.
DR   Proteomes; UP000232684; Unassembled WGS sequence.
DR   Proteomes; UP000754359; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:PKC42134.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030673};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PKC42134.1}.
FT   REGION          116..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..145
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  83784 MW;  E96AFF50BDBA8573 CRC64;
     MHKIKVLELY CGIGGLHYSL LQAFNNFVHA NKITEKKCDT YKDGIHNHMS NNKSIEIHKY
     HDCTLTCLND LFCFISVDLN PVANQTYFHN FKDSTILLTQ TRDVHKFFKW KCDSMDKQSN
     GSTHNEHEKT QKKKNKKKNN DDDEKNNIFN INKNYIIQTD INNIMPEFLN NHHFNILLIS
     NPCQPYTRQN QKFKEINLDL LFCKNNEYKQ NVNNNISNDN NSFYSNHNGD ENHQFNVDNI
     NIDELNNYIY NDKDERTKSF IHICTLLTKV DFKNLPEYIF IENVKNFELS SSFIYFLYCI
     KNNYSFQTYL LSPLQFGIPN ERLRFYCICK KKNYDFKHAN NLSGINYIKD KNLNLYTNSL
     IPKNYLHKNN IHEQKNNQGD NYNNISCENV IFYTPNLITY LDVNNNFNIT NNIWNHINIY
     NNYLDNYQVQ NQVLQKNASY CFDIININKK TTTCCHVANY YHHHHQKKKE NVNNISPDEP
     TKHMNAKGNY AMCFTSNYGR YIKGSGSILY YNRKENSNCA EQKTKNKETN VLTKENNEYV
     HTSNYTCNSI SNSDNDTYET RRKKNCMKKY EQNVRYFTPT EISRLMGFKM KTNNKNINQN
     EKGKNTYGNV FWNIDHINHT CAYFSNVHYC DVQNKNACLL TYQNVTNLNN NHTYQNCHQK
     NCLCHEFVFP NFLTDRQKYK LIGNSVNVIV ISYIFHVHNI FEHIHI
//