ID W7KKU3_9CREN Unreviewed; 646 AA.
AC W7KKU3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=3-hydroxypropionyl-CoA synthetase {ECO:0000313|EMBL:KJR79078.1};
DE SubName: Full=Acetate-CoA ligase {ECO:0000313|EMBL:EWG07995.1};
GN ORFNames=ASUL_00035 {ECO:0000313|EMBL:EWG07995.1}, TQ35_03875
GN {ECO:0000313|EMBL:KJR79078.1};
OS Candidatus Aramenus sulfurataquae.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Aramenus.
OX NCBI_TaxID=1326980 {ECO:0000313|EMBL:EWG07995.1, ECO:0000313|Proteomes:UP000054284};
RN [1] {ECO:0000313|EMBL:EWG07995.1, ECO:0000313|Proteomes:UP000054284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AZ1-illumnia {ECO:0000313|EMBL:EWG07995.1};
RX PubMed=24604657;
RA Servin-Garciduenas L.E., Martinez-Romero E.;
RT "Draft Genome Sequence of the Sulfolobales Archaeon AZ1, Obtained through
RT Metagenomic Analysis of a Mexican Hot Spring.";
RL Genome Announc. 2:e00164-14(2014).
RN [2] {ECO:0000313|EMBL:KJR79078.1, ECO:0000313|Proteomes:UP000053480}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AZ1-454 {ECO:0000313|EMBL:KJR79078.1};
RA Servin-Garciduenas L.E., Martinez-Romero E.;
RT "Metagenome Sequencing of an Archaeal-Dominated Microbial Community from a
RT Hot Spring at the Los Azufres Geothermal Field, Mexico.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWG07995.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ASRH01000001; EWG07995.1; -; Genomic_DNA.
DR EMBL; JZWS01000024; KJR79078.1; -; Genomic_DNA.
DR AlphaFoldDB; W7KKU3; -.
DR PATRIC; fig|1326980.6.peg.8; -.
DR Proteomes; UP000053480; Unassembled WGS sequence.
DR Proteomes; UP000054284; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EWG07995.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054284}.
FT DOMAIN 18..71
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 74..460
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 521..599
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 646 AA; 73728 MW; 34D218914D0DE775 CRC64;
MSQQENLPFE ERYYQPPYKA LYRESMEYPE KFWRKMAQEL EWFSPYEKVL NDSNAPFFRW
FEGGKINVTY NSLDRHLKER GNKVALIWEN EKGENRSISY LQLYNEVNKF AYALQQLGVK
KGDRAVIYLP LMPELPIAML ALARIGAIHS VVFSGFSVQA LVDRINDAKA KLVITTTHTL
RRGKRVELKG IVDQAVEQTP SVEKVLVIKR DEEPKINEKR DVIYQELTRR MPYKKVEPEE
TSATDPLFIL YTSGTTGKPK GIFHLHGGYG LWTYLTTKWV FDLRDNDVFF NTADIGWITG
HSYIVYGPLQ NGATTLMYEG VPDYPSPDRW WELVEKYGVT VFYTSPTAIR TLMRYGEEWV
KNHDLSNLRI LGSVGEPINP EAWRWYFKNV GGSQLPIVDT WWQTETGGIM ISATPGLGNY
MLKPSANGLP LPGVDADVIN EEGLPAKARE KGYIVVKRPW PGMLAGVWND PDRYIKTYWS
KFQGLYYPGD YAVKDEDGFF YILGRADEVL KIAGHRIGTR EIEDILISHP AVAESAVIGV
PDPVRGEVAV AAVVLKQGHS PNEQLKKELE DYVKKNLGAI VVFKGIYFVT KLPKTRSGKI
MRRLVRAVIS GQNLGDTSTL EDEASVEELK KAIEEFTKEI REQQKP
//
