ID W7KLC0_9CREN Unreviewed; 661 AA.
AC W7KLC0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=ASUL_05793 {ECO:0000313|EMBL:EWG07008.1};
OS Candidatus Aramenus sulfurataquae.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Aramenus.
OX NCBI_TaxID=1326980 {ECO:0000313|EMBL:EWG07008.1, ECO:0000313|Proteomes:UP000054284};
RN [1] {ECO:0000313|EMBL:EWG07008.1, ECO:0000313|Proteomes:UP000054284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AZ1-illumnia {ECO:0000313|EMBL:EWG07008.1};
RX PubMed=24604657;
RA Servin-Garciduenas L.E., Martinez-Romero E.;
RT "Draft Genome Sequence of the Sulfolobales Archaeon AZ1, Obtained through
RT Metagenomic Analysis of a Mexican Hot Spring.";
RL Genome Announc. 2:e00164-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWG07008.1}.
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DR EMBL; ASRH01000005; EWG07008.1; -; Genomic_DNA.
DR AlphaFoldDB; W7KLC0; -.
DR PATRIC; fig|1326980.6.peg.1147; -.
DR Proteomes; UP000054284; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005739; TopoI_arch.
DR InterPro; IPR006171; TOPRIM_domain.
DR NCBIfam; TIGR01057; topA_arch; 1.
DR PANTHER; PTHR11390:SF26; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EWG07008.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Reference proteome {ECO:0000313|Proteomes:UP000054284};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 7..140
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 661 AA; 75692 MW; 77F993F94EBEB70F CRC64;
MVDKKPYVVI IAEKPKAGKK IAEAFGKYFQ LSYRNVKYWK ASFNGEQIVI VTAAGHLYGL
HGASGFPVYD MSWEPLWKID KKAYYTKKYM DLINYVAGNA KFFVNACDYD IEGSVIGYLI
IDKLRGIANA KRMKINALTK EEILRAYSNL QPLDLTMVDA GIARHKVDWL WGINVSRALM
LSVKKVSGKR VILSAGRVQS PTLLQVVNRE MERYLHLPLP EFKVKVKVEI KGRVFDAPLE
GRFNVLSEAK ELAERLKRDV LFVERVSVDK TRLVRPPPFN LIDLQLEAGR LFGFSPYKVE
RLAEELYLDG LISYPRTNSQ KIPPTVNVRE IVEGVSRGPL GYLVSLLNKL THGRYVVRQG
EKDDPAHPAI YPTQYFGSRL PRDQYKLYEL IVRRFLASMS VDAWIERQSV ALRFKRSGLK
LSLSLQEVVE KGWLEIYPYV KVKDEALLEV KEGEEVNVKG ISVITSLSKP PQRFSKTTLL
KWMESSNLGT EATRGRIIET LFERKYVKLS GKSIVPTKLG IVIAEVLDKF FGELTDVKMT
ADMEQKLNDI IYGKTNSEEV VKEMREKIAK YVEVFDSNKE KIGEKIAKGL GYLQYQKCKY
CDFEAENGGL CRYHLNAMEK VKEGINEWTI RTGYPRDRVI KSLEKSKYTG KFVLDVVKEM
M
//
