ID W7LHF5_GIBM7 Unreviewed; 796 AA.
AC W7LHF5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=FVEG_01331 {ECO:0000313|EMBL:EWG37936.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG37936.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG37936.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS022242; EWG37936.1; -; Genomic_DNA.
DR RefSeq; XP_018744127.1; XM_018888253.1.
DR AlphaFoldDB; W7LHF5; -.
DR GeneID; 30059637; -.
DR VEuPathDB; FungiDB:FVEG_01331; -.
DR OrthoDB; 1329523at2759; -.
DR Proteomes; UP000009096; Chromosome 1.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09393; LIM3_Lrg1p_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF1; RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 108..171
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 443..647
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 200..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 88222 MW; F4909BE57E7B5562 CRC64;
MSYGREAKLL CKKIVSFFSL LSKTQDNATH KLGVTQELLS LVTGLAHYLK LLIRICLQGA
LRLEREASAS TGLYQFLDDL SDLDAIKNDD GQLSVTASGG KLSANDSDHC SLCHRSVEDE
CAKNGDLRWH LNCVKCTRCG RDVGRSLQEA CLNALDRKIY CTNCAGANAL PLEHVSKLQQ
YVFLLRVALA RLLDILKANG TLPRSKDDND NNGYGTGDGQ GSDPRSRGGD SQSRGPGGSK
RESSYENTLN DVRRLRSTRL DRHLSSSARQ ARSSRVMDTD GKGPRPGSSG DAGQGHGAQG
STDIMFGQND GITLDDISRI VAVEQSRDLQ QKAPQPFQDR SLDASSSNQG HLRTQSADRE
RTETVQERIG RRFFSELSGL EYFNVRHLAV LTMQPMIEQE FSLEELLSFI ESRKQGASIW
KNIGKAFKND KSKNVKKKGV FGVPLEIIIE RDGAESTDGV GPGTLRIPAV IDDIVSSMRK
MDLSVEGVFR KNGNIKKQQG LVDTINAEGC DVVNFMEQPV VQLAALLKRY LRDLPDPLMT
HKLYRLWISA AKISDPEKRK RCLHLTCCLL PKSHRDCLEI LFSFLKWAGT FHQLDEDLGS
KMDTRNLATV IAPNILTNPN RAPALDSEAM YVIDAVEMMI THIEEMCQVP DEILGLMNDP
YIFTNSGDLT TKDILKRFQD RRGQISIADV NEVYNRQDNS TRPPARRVET DPAVWQGEAT
VRTIQDPSMP NPNNGHGTPP ARFRGRNDLG NASPYGVNQF NQSDSQLDSA EHSRRREWRN
SGMGRQGSGL GVSGNS
//
