ID W7LQS1_GIBM7 Unreviewed; 422 AA.
AC W7LQS1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Cystathionine gamma-lyase {ECO:0000313|EMBL:EWG37860.1};
GN ORFNames=FVEG_01304 {ECO:0000313|EMBL:EWG37860.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG37860.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG37860.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7600 {ECO:0000313|EMBL:EWG37860.1}, and M3125 / FGSC 7600
RC {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2] {ECO:0000313|EMBL:EWG37860.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7600 {ECO:0000313|EMBL:EWG37860.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; DS022242; EWG37856.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37857.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37858.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37859.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37860.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37861.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37862.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37863.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG37864.1; -; Genomic_DNA.
DR RefSeq; XP_018744047.1; XM_018888191.1.
DR RefSeq; XP_018744048.1; XM_018888192.1.
DR RefSeq; XP_018744049.1; XM_018888193.1.
DR RefSeq; XP_018744050.1; XM_018888194.1.
DR RefSeq; XP_018744051.1; XM_018888195.1.
DR RefSeq; XP_018744052.1; XM_018888196.1.
DR RefSeq; XP_018744053.1; XM_018888197.1.
DR RefSeq; XP_018744054.1; XM_018888198.1.
DR RefSeq; XP_018744055.1; XM_018888199.1.
DR AlphaFoldDB; W7LQS1; -.
DR STRING; 334819.W7LQS1; -.
DR EnsemblFungi; FVEG_01304T0; FVEG_01304T0; FVEG_01304.
DR GeneID; 30059612; -.
DR KEGG; fvr:FVEG_01304; -.
DR VEuPathDB; FungiDB:FVEG_01304; -.
DR eggNOG; KOG0053; Eukaryota.
DR HOGENOM; CLU_018986_2_3_1; -.
DR OMA; YKQDGVG; -.
DR Proteomes; UP000009096; Chromosome 1.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:EWG37860.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 216
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 422 AA; 44691 MW; AB06B2CBE7CF2E6A CRC64;
MSAAPLNSDP VATPPRPPSP VHSFGTLAVH AGAPHDPATG AVIESISLST TFAQSAVGKP
VGEYEYSRSA NPNRTNFETA VAALEHAKYA LAFSSGSATT ATILQSLAAG SHVISVSDVY
GGTHRYFTQV AKAHGVKVTF TPEIEVDISE HITPDTRLIW IESPSNPTLR LVDVRAVVSE
AHKHGVLVVV DNTFLSPYVQ NPLDFGADIV VHSVTKYING HSDVVMGVAA FNSDELKNRL
SFLQNAIGAV PSAFDSWLAH RGLKTLHLRA REASRNADAV ARALEASPLV IAVNYPGLDS
HPHRHIAKKQ HRDGLGGGML SFRIQGGHAA AERFCQVTKI FTLAESLGGV ESLVEVPSSM
THAGIPRDQR EAVGIFDDLV RISCGVEDAQ DLTNDVLQAL EKATSAVKTN GFNGNGNGVN
GS
//
