ID W7LWE8_GIBM7 Unreviewed; 768 AA.
AC W7LWE8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Glycosyl hydrolase {ECO:0008006|Google:ProtNLM};
GN ORFNames=FVEG_04999 {ECO:0000313|EMBL:EWG43583.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG43583.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG43583.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC {ECO:0000256|ARBA:ARBA00005641}.
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DR EMBL; DS022246; EWG43583.1; -; Genomic_DNA.
DR RefSeq; XP_018749774.1; XM_018892979.1.
DR AlphaFoldDB; W7LWE8; -.
DR EnsemblFungi; FVEG_04999T0; FVEG_04999T0; FVEG_04999.
DR GeneID; 30063022; -.
DR KEGG; fvr:FVEG_04999; -.
DR VEuPathDB; FungiDB:FVEG_04999; -.
DR eggNOG; ENOG502QPU8; Eukaryota.
DR HOGENOM; CLU_009024_0_1_1; -.
DR OMA; MWQTFLT; -.
DR OrthoDB; 69117at2759; -.
DR Proteomes; UP000009096; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0050295; F:steryl-beta-glucosidase activity; IEA:EnsemblFungi.
DR GO; GO:1904462; P:ergosteryl 3-beta-D-glucoside catabolic process; IEA:EnsemblFungi.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR041036; GH5_C.
DR InterPro; IPR001547; Glyco_hydro_5.
DR InterPro; IPR018087; Glyco_hydro_5_CS.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR31308; -; 1.
DR PANTHER; PTHR31308:SF5; ERGOSTERYL-BETA-GLUCOSIDASE; 1.
DR Pfam; PF00150; Cellulase; 1.
DR Pfam; PF18564; Glyco_hydro_5_C; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00659; GLYCOSYL_HYDROL_F5; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 65..253
FT /note="Glycoside hydrolase family 5"
FT /evidence="ECO:0000259|Pfam:PF00150"
FT DOMAIN 642..731
FT /note="Glycoside hydrolase family 5 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18564"
FT REGION 590..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 86901 MW; 81FB0D0AC9F1F3FF CRC64;
MSSFRLLIED GQFRDGYGRQ VVLRGINLAA DAKLPSEPDQ PSHIPTDFFD GDNVTFHQRP
FPKEDARSHF ARLRRYGFNT IRYIFTWEAL EAAGPGKYDE GFIQHTIDIL RIAKEYGFYI
FMDPHQDVWS RFTGGSGAPL WTIYACGLNP QSFAATEAAI VQNTYHNPDE FPKMIWSTNY
YRLAAGTIFT MFFAGKDFAP KCIIDGVNIQ DYLQDHFMRA CGQLAQRIHE AGDLENVVVI
GWESMNEPNK GMTGYKDLTV IPKEHPLKKG TCPTMWQTLL TGMGRACEVD TWEMGGLGPY
KTGTTLVDPH GEVAWLPADY DDSRYGWKRD PGWKLGKCVW AQHGVWDMET DTLLRKDYFA
KNPNTGKVID YPQFTNTYFM DFWRKYVKTC RAVHKDCIML MQFPTLELPP EIKGTEDEDP
RMAFTPHYYD GITLMTKHWN STWNVDVVGV LRGKYWHPAL AIRIGETAIR NCLRDQLATL
RQEGLDRIGK HPCVLSEFGI PYDMDDKKAY KTGDYSSQSA AMDANYFAVE GSQIEGHCLW
TYCARNDHLR GDFWNGEDLS ILSLDDKPLP ESPVPEYSQS SLDLARTATA ANTKKDVADD
RNVTPDNLKR TLTNPSISSA PSAKDPQLTN APGFRAAEAF VRPTPTVVYG DIVSTGFDLR
QCTYLLKVKA PRAAPDEAPT IVYLPEYHFP KEQCEVAVSS GKWELSTDDE EGTTLQKLKW
WHAEGEQSLK ISGLVRKHNV PVGSEEDAGY LEQCQQGYGF NFGSCSVM
//
