ID W7M2R0_GIBM7 Unreviewed; 757 AA.
AC W7M2R0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Protein disulfide-isomerase {ECO:0000313|EMBL:EWG45296.1};
GN ORFNames=FVEG_06137 {ECO:0000313|EMBL:EWG45296.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG45296.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG45296.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; DS022248; EWG45296.1; -; Genomic_DNA.
DR RefSeq; XP_018751487.1; XM_018894405.1.
DR AlphaFoldDB; W7M2R0; -.
DR STRING; 334819.W7M2R0; -.
DR EnsemblFungi; FVEG_06137T0; FVEG_06137T0; FVEG_06137.
DR GeneID; 30064056; -.
DR KEGG; fvr:FVEG_06137; -.
DR VEuPathDB; FungiDB:FVEG_06137; -.
DR eggNOG; KOG0191; Eukaryota.
DR HOGENOM; CLU_021868_0_0_1; -.
DR OMA; IFVYFYD; -.
DR OrthoDB; 52245at2759; -.
DR Proteomes; UP000009096; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd02961; PDI_a_family; 2.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 2.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:EWG45296.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..757
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004896330"
FT TRANSMEM 706..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..158
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 287..405
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 156..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 85613 MW; 09E871B4062A4BC2 CRC64;
MRFSPLAILA GLSAVALAEE ERNPVTDPTT FNGKSVPPFK ELTPSNWEEE TKKNKFWMVK
HYSPYCKHCT RFAPTFQTLY EFYYTSKPPT ENPDDTFTKY YDFAFGTVNC VAYYDFCMDH
NIQSYPTTIL YEDGKVFDTL RGIKNMTALT TSVENALSKT HPGRPALVEL PQPGDTVYPA
PKAEEPAAEK KVEGTQGDAK APVEKPAVNA EKPLDAAAEK PVEEPAGKNA GKSLDDITES
PKDAEKSDKT ESTEKKPEES AAAKDENKNT FGADWKVPST GQMLKKTKPK DTTPKYNLEG
TSVPLTPENF DKLVTSSKDP WFIKFYAPWC SHCKAMAPTW QQLAKNMQGK LNIGEVNCEA
DHKLCTQMGV KAFPTIYFVT GTEKAEYKGL RGVGDFVAYA EGALEVAGGV VDVDAESFKE
LEKTEEVLFV YFYDHATTTE DFKALDALPL NLIGRGKIVK TSDQELCSRF KITTWPRLLV
SREGRATYYT PITPDEMRDV DSLTSWMKST WLPLVPEMTA INAKQIMSHK LVVLAILNRN
DEDRLQNSIS ELKNAANEWV DRQVQEFQLE RKKLRDAKQM RIEEAQSRDD QRALRNAKAI
KIDMDSTHRK EVGFAWVDGI FWQRWIATTY NIDVRDGERI IINEEDRHQF WDTTPTGNQI
MVSHTSIMDT LDKIVYGPNP ISPKYTIGTL AKFFFDIKMN FVDHPFLSIG LIIAVGFGLY
SWIRNRTRRS RGTFFRMDDS LGLKDGLLGQ NGNDKSD
//
