ID W7M657_GIBM7 Unreviewed; 1055 AA.
AC W7M657;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=FVEG_07294 {ECO:0000313|EMBL:EWG47058.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG47058.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG47058.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS022250; EWG47058.1; -; Genomic_DNA.
DR RefSeq; XP_018753249.1; XM_018895893.1.
DR AlphaFoldDB; W7M657; -.
DR STRING; 334819.W7M657; -.
DR GeneID; 30065112; -.
DR KEGG; fvr:FVEG_07294; -.
DR VEuPathDB; FungiDB:FVEG_07294; -.
DR eggNOG; KOG1144; Eukaryota.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000009096; Chromosome 8.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EWG47058.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 460..678
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 115975 MW; BB5C6893E3B68F88 CRC64;
MPPKKKGNKK NQQDDWEAEL GESIAPPTNA NGADGDANAN DDDDDAGGAG GLMATLRKNK
EKRKKKGIVE PEPEPEPEAP AAQEPPAQAP VEANIDDEFA LPEKKGKGGK QNKQAAKKPE
PAAAAEDAAD GGRILTKAEK EKLKKEREKQ RKKEQAAAKK KGGAAPKAAP EVKEKEEAAP
VEAAPVPEPA AGGKKKKLPA HLALLQKQQE ELKRQREEAA RAEAEAKAQA EEDERLAAEE
EKRREEAKAI KKQKERERVE QLKKEGKYLT KAQKEEKARN ERKLQQMLAA GIQVGPAGEP
SEKKSKPADN RRKKGRAQQK IDEEKALAEA AERARQEAEK ALKEAEEKAA REKAEAEAKA
AAEKKGAESD VEDDWEAAAA SDGDVKDSWD ADSDEEAEKA NGTSEAKAEE ESGEESEEES
SDDEAATAAQ LAEEKRKREA AERREKAHQA ALAARSKDNL RSPICCILGH VDTGKTKLLD
KVRQTNVQEG EAGGITQQIG ATYFPVEAIR QKTAVVNPDG KFEFKVPGLL IIDTPGHESF
SNLRSRGSSL CNIAILVVDI MHGLEPQTLE SMRMLRERKT PFIVALNKID RLYGWKQVAN
NGFQDSLALQ SKAVRNEFET RLEKTKIAFA EQGFNSELFY ENKSMSKYVS LVPTSAHTGE
GVPDMLKLIV QLTQERMVGS LMYLSEVQAT VLEVKAIEGF GMTIDVVLSN GILREGDRIV
LCGTEGAIKT NIRALLTPAP MKELRLKSAY VHNKEVKAAL GVKISAPGLE GAIAGSRLMV
VGPDDDEDDI EDEVESDLAV LFNRVEKTGR GVSVQASTLG SLEALLDFLK DCKIPVANVG
IGPVYKRDVL QCGVMLEKAP DYAIMLCFDV KVDKEAQQYA EDNGIKIFTA DIIYHLFDAF
TKHMDEQLEK KKEESKMLAV FPCVLKPVKV FNKNDPIVIG VDVTEGQLRI NCPVAAVRNN
PTTGAKEIVK LGRVTSIERE HKQIPVCKRK EPSVAIKIEM GGNQPMYGRH LEEDETLYSL
ISRASIDTLK EYYRKEVSND EWQLIIKLKP LFDIS
//
