ID W7M862_GIBM7 Unreviewed; 720 AA.
AC W7M862;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN ORFNames=FVEG_05035 {ECO:0000313|EMBL:EWG43654.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG43654.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG43654.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7600 {ECO:0000313|EMBL:EWG43654.1}, and M3125 / FGSC 7600
RC {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2] {ECO:0000313|EMBL:EWG43654.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7600 {ECO:0000313|EMBL:EWG43654.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; DS022246; EWG43652.1; -; Genomic_DNA.
DR EMBL; DS022246; EWG43653.1; -; Genomic_DNA.
DR EMBL; DS022246; EWG43654.1; -; Genomic_DNA.
DR RefSeq; XP_018749843.1; XM_018893036.1.
DR RefSeq; XP_018749844.1; XM_018893037.1.
DR RefSeq; XP_018749845.1; XM_018893038.1.
DR AlphaFoldDB; W7M862; -.
DR STRING; 334819.W7M862; -.
DR GeneID; 30063056; -.
DR KEGG; fvr:FVEG_05035; -.
DR VEuPathDB; FungiDB:FVEG_05035; -.
DR eggNOG; KOG1461; Eukaryota.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000009096; Chromosome 4.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000313|EMBL:EWG43654.1};
KW Protein biosynthesis {ECO:0000313|EMBL:EWG43654.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 532..718
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 79706 MW; 6028298C33AC8A28 CRC64;
MSHKGNSGKG KKSSKTGAES KSEDVLQAVV LADSFQDRFK PFTTEKPRCL LPLANTPLIE
YTLEFLAMNG VNEVYIYCGA HTDQVEDYIS RSRWSAAART SPFSVLQFVR VSDARSAGDV
LRDMDKRSLV DGDFILVHGD LVSNIMLDGA LAAHRKRRQD SAANIMTMVL RSGGEDDHRT
KTNGITPIFV VDTKTQRCLH YDEMSPLASD RYMSLDPAVV DELSTEFEIR SDLIDAQIDI
CTPEVLALWS ESFDYELPRR NFLHGVLKDW ELNGKMIYTE ICEEGYAARA SNLQQYDAIS
RDILGRWTYP FIPECNIVPK QAYQRHRPGV VVEHGAFYAN TSQVQNSVIG RNSYIGPESR
ISNCIIGRDC KIGKNVILKD CYIWDDTTVG DDARIYRSIV ADSVTIGENS TIAEGSLISF
GATIGKSISP PKDTVISCVD SKGNPLTPDT ELLGSGTNAA AFKDPEDDEV DERDPCQLQK
SLMYNLFQFN ISTSSVSTLS SEISEDIPDE NSLHVDTTDP SRRTSFASDD AGDKLSFHSE
AVHGLVDALR AESGDFDSAK LEFMGLRLSN DASDAMMRRA VATAFARHAV DLMTPEHGNL
EPSKAAEQAL RARKGAAKFI NEVGIGGDDD NEAEQVEFII ALQKALTRSQ GPEQSRVGTL
LAAMLQQLYA LDILEEEGIL SWWGNERTVE GEAMTLLKEK CRVLVEWLEN AEEEDDSDEE
//
