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Database: UniProt
Entry: W7MEM1_GIBM7
LinkDB: W7MEM1_GIBM7
Original site: W7MEM1_GIBM7 
ID   W7MEM1_GIBM7            Unreviewed;      1094 AA.
AC   W7MEM1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Na(+)/K(+)-exchanging ATPase {ECO:0000256|ARBA:ARBA00039096};
DE            EC=7.2.2.13 {ECO:0000256|ARBA:ARBA00039096};
GN   ORFNames=FVEG_09346 {ECO:0000313|EMBL:EWG50008.1};
OS   Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS   fungus) (Fusarium verticillioides).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC   Fusarium fujikuroi species complex.
OX   NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG50008.1, ECO:0000313|Proteomes:UP000009096};
RN   [1] {ECO:0000313|EMBL:EWG50008.1, ECO:0000313|Proteomes:UP000009096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX   PubMed=20237561; DOI=10.1038/nature08850;
RA   Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA   Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA   Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA   Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA   Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA   Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA   Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA   Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA   Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA   Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA   Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA   Kistler H.C., Rep M.;
RT   "Comparative genomics reveals mobile pathogenicity chromosomes in
RT   Fusarium.";
RL   Nature 464:367-373(2010).
CC   -!- FUNCTION: This is the catalytic component of the active enzyme, which
CC       catalyzes the hydrolysis of ATP coupled with the exchange of sodium and
CC       potassium ions across the plasma membrane. This action creates the
CC       electrochemical gradient of sodium and potassium ions, providing the
CC       energy for active transport of various nutrients.
CC       {ECO:0000256|ARBA:ARBA00037422}.
CC   -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC       catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC       additional regulatory subunit. {ECO:0000256|ARBA:ARBA00038795}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; DS022253; EWG50008.1; -; Genomic_DNA.
DR   RefSeq; XP_018756199.1; XM_018898334.1.
DR   AlphaFoldDB; W7MEM1; -.
DR   EnsemblFungi; FVEG_09346T0; FVEG_09346T0; FVEG_09346.
DR   GeneID; 30067005; -.
DR   KEGG; fvr:FVEG_09346; -.
DR   VEuPathDB; FungiDB:FVEG_09346; -.
DR   eggNOG; KOG0203; Eukaryota.
DR   HOGENOM; CLU_002360_4_1_1; -.
DR   OMA; CYIAYSV; -.
DR   OrthoDB; 203629at2759; -.
DR   Proteomes; UP000009096; Chromosome 5.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR   InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01494; ATPase_P-type; 2.
DR   PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR43294:SF13; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR   Pfam; PF13246; Cation_ATPase; 1.
DR   Pfam; PF00689; Cation_ATPase_C; 1.
DR   Pfam; PF00690; Cation_ATPase_N; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00121; NAKATPASE.
DR   SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SMART; SM00831; Cation_ATPase_N; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        150..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        923..951
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        986..1003
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1024..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1055..1073
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          101..174
FT                   /note="Cation-transporting P-type ATPase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00831"
FT   REGION          22..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1094 AA;  121013 MW;  9D34FE62D43B6002 CRC64;
     MIEDEKKDVA VFGERIHWND DDEAGRVSRH GERRSRRRSR SRSRDSLSIH RAGSRNRADP
     SLVLPVTYRT VSFNIEESKG KEQAELAKAK DVTTKALTDL EWHTIAPFDV EKRLTTSSTA
     GLSTEQAERR QREYGRNAPS PAKTHWFRTI FLYFFGGFGS ILLTGCILVF VSWKPLGDPP
     AVANLALAIV LLAVFFIQAL FNMFQDWSTS RTMSSIKNML PEEGHVIRDG NLVDLNAAEI
     VPGDVIKVKA GNKLPADIRL IEASSDVKFD RSVLTGESKP VAGTVDHTDT NYLETHNIGL
     QGTHCILGSC TGIVVATGDR TVFGRIASLT NEPKVQMTTL EKEVLYFVII IASIMISMIA
     VVCIIWGAFL KKKHPDFINV PTLIVNCVSV AIAFIPEGLP ISITAGLTIT ANLMKKNKIL
     CKSLKTVETL GSVSVICSDK TGTLTTAKMA VSDCAVGGLN MTIENARGKF GQSKSTTHPI
     IQLRALAALC NASEFDAATK DAPLADRRIF GDATDQAVLR FAEFVDPSSV GYLRACWNKI
     YDLAFNSKNK FMIRCFSCTR TEAVAATLSK ETAFNNDDIL LTIKGAPDVL IGRCSYYVSE
     HGETIPLNAA MRATVEQLKN TYSSQGKRCL LLARKIIKNS DLPKNRETSE FEHAVTRESN
     TGLTFVGMVA IVDPLRHDIP HVVSTLRGAG IRIAMVTGDF ALTALAIARE AGIVTSQTVD
     DSTALQRYRP DDTKDSPISH LGAIVLSGPE LMSLNEHQWE TLTHYEEIVF ARTTPEQKLR
     IVREFQKGNV VAMTGDGVND APSLRAADVG ISMGSGSDIA MEAADMVLLD TFSSIIIAVQ
     YGRVVFDNLK KVISYLLPAG SFSEFWPVMA FVAFGLPQAL SSFLMIIICC FTDCAAATML
     SYEKPEADVL TRPPRNIKKD RLVNWQLILQ AYGVNGVLQT VASFAMAFWY LQRQGIPFSE
     LWFSFGKLPA GIDPDYYLAK TNEASSIYFV NLVVMQWFNL MATRTRRLSI FQHPPLFNPN
     TQNWYLFPAI IFSLAMAIFW LYIPPLQPVL GTTPVPVEHW FLPFAFGIFQ LLLDEARKFG
     VRKWPHGILA KLAW
//
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