ID W7MKC4_GIBM7 Unreviewed; 740 AA.
AC W7MKC4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Malate dehydrogenase (Oxaloacetate-decarboxylating)(NADP+) {ECO:0000313|EMBL:EWG48040.1};
GN ORFNames=FVEG_07972 {ECO:0000313|EMBL:EWG48040.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG48040.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG48040.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=7600 {ECO:0000313|EMBL:EWG48040.1}, and M3125 / FGSC 7600
RC {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2] {ECO:0000313|EMBL:EWG48040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=7600 {ECO:0000313|EMBL:EWG48040.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Corby-Kistler H., Broz K., Gale L.R., Jonkers W., O'Donnell K.,
RA Ploetz R., Steinberg C., Schwartz D.C., VanEtten H., Zhou S., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
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DR EMBL; DS022251; EWG48037.1; -; Genomic_DNA.
DR EMBL; DS022251; EWG48038.1; -; Genomic_DNA.
DR EMBL; DS022251; EWG48039.1; -; Genomic_DNA.
DR EMBL; DS022251; EWG48040.1; -; Genomic_DNA.
DR RefSeq; XP_018754228.1; XM_018896713.1.
DR RefSeq; XP_018754229.1; XM_018896714.1.
DR RefSeq; XP_018754230.1; XM_018896715.1.
DR RefSeq; XP_018754231.1; XM_018896716.1.
DR AlphaFoldDB; W7MKC4; -.
DR STRING; 334819.W7MKC4; -.
DR EnsemblFungi; FVEG_07972T0; FVEG_07972T0; FVEG_07972.
DR GeneID; 30065736; -.
DR KEGG; fvr:FVEG_07972; -.
DR VEuPathDB; FungiDB:FVEG_07972; -.
DR eggNOG; KOG1257; Eukaryota.
DR HOGENOM; CLU_011405_2_0_1; -.
DR OMA; QQAFMDE; -.
DR OrthoDB; 1069499at2759; -.
DR Proteomes; UP000009096; Chromosome 3.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05312; NAD_bind_1_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23406; MALIC ENZYME-RELATED; 1.
DR PANTHER; PTHR23406:SF32; NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 239..419
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 429..696
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 90..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 82151 MW; DC261B04EF7332D0 CRC64;
MGQTLSTMTV ASPSGPGSAQ NVLNRLFFAS GPLRSATSST LTRASTRSST VVPPVTVLTA
TTNNRRPRPS IPRLSYPSFF PFSSPHLSLS MSMASSSPHS TASSEIATPR SRSSTASSPR
RLTDSNPMSP VDLSKIEQEI KMAALDQHRG YVQDHYAEVK QDRTPEYVDE SNAAGYQIVR
EPLWNKGLAF TPEERASKNL TGLLPHTMES FETQCARAMK MIQTRQTPID KYLYLSTLKD
QNTDLFYRLL IDNIRELMPL VYTPTIGDVC LQYSSIYTRP EALYISIKQR KSIRAMLRNW
PCQDPEICVI TDGSRILGLG DLGINGVGIS IGKLALYTGA AGIHPSKTLP IVLDCGTNNE
ENLRDPFYLG LRQKRPSYPE QQAFMDEFME AAREVFPSMV VQFEDFDSEK AFGYLDRYRN
QYRCFNDDIQ GTGAVVLGGY IGAVEQSGVP IEEQRLVFMG AGSAGVGVAK QLVEYYTRRG
LSEAAARDKF WLVDTKGLVT KDRGDRLAEH KKYFARTDNN GHQYRTLEEV IEYVKPSALV
GLTATFGVFT EPVVRALKNS VQEGGLERRP ILFPLSNPLT KAECTFEQAI EWTEGTVLFA
SGSPFNPVKA KFGDETHHTV YHPNQGNNVY IFPGLGLGAI LAKASRITDE MVYTSAAALA
GSLNADEVHK GLIYPRIERV RDASVIVARE VMKAARRGGV SELPESQWAE WEEWGDVALT
TYIKQRIYNP LCFADAKTHL
//
