ID W7MU19_GIBM7 Unreviewed; 337 AA.
AC W7MU19;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:EWG51264.1};
GN ORFNames=FVEG_10301 {ECO:0000313|EMBL:EWG51264.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG51264.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG51264.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
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DR EMBL; DS022255; EWG51264.1; -; Genomic_DNA.
DR RefSeq; XP_018757455.1; XM_018899395.1.
DR AlphaFoldDB; W7MU19; -.
DR STRING; 334819.W7MU19; -.
DR GeneID; 30067898; -.
DR KEGG; fvr:FVEG_10301; -.
DR VEuPathDB; FungiDB:FVEG_10301; -.
DR eggNOG; KOG1097; Eukaryota.
DR OrthoDB; 20281at2759; -.
DR Proteomes; UP000009096; Chromosome 9.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR CDD; cd00443; ADA_AMPD; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 7..332
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 337 AA; 37946 MW; 876702D7C8069228 CRC64;
MDFVGLPKIE LHAHLTGSIS RRALHEVWLR KKETGSTDLE DPLIVMPEGK HDYNLQTFFP
LFSSYIYNLI TDEESVRDTT KSVLKDFLND GVCYLELRTT PRTTPQLSAE RYISTLLDVV
SSFESQNPQL HTRLILAVDR RHTPEQAAST LELALTYREQ GVVGLDLCGD PTARPSGEIS
VFTPVFLEAK KKGLGITVHF AEAEASGSKE ELNTLLSWEP DRLGHVIWED EEIKREIARR
GLCLELCLSC NVRAGMVLGG FEGHHFGHWR GVNGPKISLS TDDVGVFGSP LSNEYRLVAE
HFGLDRQAIC KLSRQPIDGI FGGEREKERL KDIMWTR
//
