ID W7N083_GIBM7 Unreviewed; 4074 AA.
AC W7N083;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=FVEG_11932 {ECO:0000313|EMBL:EWG53515.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:EWG53515.1, ECO:0000313|Proteomes:UP000009096};
RN [1] {ECO:0000313|EMBL:EWG53515.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
CC -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000256|ARBA:ARBA00004685}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; DS022259; EWG53515.1; -; Genomic_DNA.
DR RefSeq; XP_018759706.1; XM_018901257.1.
DR STRING; 334819.W7N083; -.
DR GeneID; 30069413; -.
DR KEGG; fvr:FVEG_11932; -.
DR VEuPathDB; FungiDB:FVEG_11932; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000009096; Chromosome 4.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..442
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2462..2537
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3666..3744
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2544..2643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2557..2612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2614..2643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4074 AA; 446835 MW; 4CED15A80C7F9232 CRC64;
MTKFSKANEP IAVVGTACRF PGGCNTPSKL WDLVFSSRDV LQKVPPARFN VDSFYHSDPT
HHGTTNVTQS YFLDEDVTKF DNGFFGIQPM EAEAMDPQQR LLLETVYDSV VDAGLAMEDL
KGSDTSVFVG QMCDDWAQML AKDWDDIPTY MGTGVSRAVM SNRVSYFALF DWHGPSMSID
TACSSSLVAV HEAVRTLRSG ESNVAVAAGA NLILLPGMYI CESKLRMISP TGRSRMWDAN
ADGYARGEGF ASVILKTLSQ ALADGDPIEC IIRETGVNQD GKTPGLTVPS NIAQTALIRD
VYQRAGLDIT KPSDRPQLFH AHGTGTKAGD PKEAEAIFRA FFGDDQPHDE KLNVISIKTQ
IGHTEGTAGL ASLLGTMMAM KNATVPPNMH FETLNPDIEP FYSNLEVPTS AKAWPNVHGS
VRRASINSFG FGGTNSHAIL ESYEPALHNQ AVATTEAESP RLYTPLLFSA NSEKALKEML
SSYLSFLEER YETNMSDLAW TLHNRRSTLP YRSSVVVPAG SGNPQEAARS AILSEIERLT
DSPHKLHRSL SVAKPKILGV FSGQGAQWPR MGAILLESSA WARAKIVELD GYLAELPASD
APDFTLESEL LAFKETSRVA EAAISQPLCT AVQVLLVDLI RELAGIQLSA VVGHSSGEIA
AAYAAGFMAR RAAIVTAYYR GRYAKLAASP SSSEIKGAMA AVGTDEGDAL EFCALEDNAG
RITVAAVNAP SSVTLSGDED AIEEAIAVFQ DEGKFARRLK VDTAYHSSHM QAAAGPYLEA
LQRSGVRFDE EFASEQRPLW FSSTKVDAAP MKRENLSPQY WIDNMVKPVM FAPALDCALA
HSGPFDMALE LGPHPALKGP ALESLGSGTP YQGVLTRGKD DVESVADCFG AVWRNLGRGY
VNFASIDATL SGRSSTPTVV RDLPPYPFTA DSQVFWSESR FCAALRQMDE PVHPILGRRM
VENSVPGMTQ WRNILRAREI PWLRGHRLQG QVIFPGCGYA AMALEAAMIL VRDLKDSPTV
RLLSLYDLTM DQAIVFNDDS SSVETLVTMK TVESSHDELV VDFVCCSYHT HGLAPAVTST
HAHGRVVARL GAPSADAIPG QTAQDPARQF NLAPIEMDRF YTELAKHGYQ YSPPFKGIVE
IERKSDFAIG KIIDQSGPEW EDQVALAHPG LMDSGVQTVL AAMAAPGDGR LWCLQMLVGI
DAIHVNPYFA SAARGATMAW EASTTLGEDA DSLGEAVGDM KMLSPDGQQA YIAVEGARMR
PFTPATAAND SPLFSTWVYG PSEPDGVLAS RVNRSKEVAD AEIRSADNLD RLSLFYVRRL
AELIPAGSKA RDEAQEHFKR LLTWCDHVIG LVSRGEHHFL TPGMMNDTQA EVDRLLAEYA
NSNDFRLTHA AAKALLEVVP ANEGNVHEYL TKDNMLNRYY EETLRYEASD QKMYNMMRQL
AHIYPQMRVL EVGAGTGGAT SHALPAIDGA FSVYTFTDIS TAFFDKAEEK FKDYFGRINF
KALDMNNSIE EQGFTESSYH VVMAGMALHA TGDVEGALRN IRRLLKPGGR LIGFENINND
AVRLGIGMGG FAAWWSGAEY GRPWGPMLTL EQWDDALKRT GFTGVDTHTV GHNQTQPMCL
WVSMARDEKV DLLREPLAAV PEKQQSLVVV GGKSLGTMDL VEKTKSLVAP FYQTTSHYRS
IEALNDITED QFPEGSSVLC LTELDEPVLR TVTDPKLDGL KTLWARGRNI LWVTKGAASE
QPYNNMVVGL ARSIRQEYPS ITLQTVDLDN ATVGDGAWVP SFVARTLRRI ELLDKWKREE
IANGADLNDK LQWTQESEVR VVEKKTYMPR LNVNKELSHR FNSIRRIIHE NVDPQSPKTS
FSLNASVNAP LAAPVIGQIS PLRVQPETDA TVPSYEVRIR KSLLQALRIS TLGYFRLCVG
DADGKRVLAL TSSAETPATT PQDLTVALPA GASEELSSMA LLSTAAHLVA AQIAALAPQP
KGSHIVIHEA DPLVRTAIMS LFESHPAPSW RVSFTGCLVE GQQPQDHPGK TTWLAQVMSS
RAIRKVLPAL ASSSLLVDFS APNSPSSIVA SAMAECLPWY ARTEKSLIRN RIEVRPGDLA
DAKAALQAAW SKASSMVIEA RDRETVPLNH IEGFTAPIGQ SLHLVDWTTP SVPVRVHPLD
HHTNIFRSDK TYLLVGLSGE MGQSCCEWMA AHGARYVVLT SRYPKVDQRF IDNMEQAGVT
VVPRKLDITS KESLHLCHQA ITRTLPPIAG VANGAMLLQD VLFKDMDAAN LNKVLAPKVN
GSIYLDELFA DTKLDFFLMF SSAASIVGSR GQANYAAANM FMASLVNNRR KRGLAASIIN
ISALIGLGYI ERQKIYDASF FKDIGIANTS AQGLHQLIAE AILAGQRFGP DEDIEGGEIS
QGIMPQFSDD EHKSFFIHDS KFSNMLIERV DGDADVDASG NAAAVSLSRQ LKRVTSKDQA
LRVIADTFTL KLKKMLRIPA ETDVPESLAL VDQGVDSLVA VDVRSWFLKE LDTDMPVLKI
LGGNSILDLA SDALERIPKA LLDLDRDGDD ANNEAQPVSD KKLTEPPTSS SSSDVVTGDS
DAVSQSSATD VSTTAKSTAG ADTASIPPSL RDMKNNNELD DRHKRELQDE TKKRRADEKA
AAERREEIVK SSSEVVDEMS LVQSRFWFLT TALEDKTTFN VTISAHLKGR IDVGKLDRAL
EGVTKRHEIL RTRFFFGGKS LETPMQGVLS KPTVHLTSRH INSKEDVDEE MEWLHSHPWD
LGGWETIKLS LLSQSDTEHW LVLAFHHIAF DGYSLEIFWS DLAKAYNANG SIPTLPDAKQ
YRAYIAKQRR QNLSKPFQWR KAIEYYRKLI MPEPEPLPLL PFAKVSHRKL LDNYSCYNAE
ITLEPSEAAR IRKLAKANHS TSFHVYVASL QTLLFGLMPD SVDRLFIAMD DTNRLDKDFM
DTIGLFVNTL FLRFDRADYN KLSLSDAVKA ARTKTYKALE HSVLPLDVLL KELCITRHGD
AVPVAQVLID YRVSHKEWFR LGDCRAEMGT GRAERQGSDL AFYILDDSDE QNGGRVRVGV
EVQSTLYDAE HAEMLIKAYA NLLRKVTADE AGSKTALKSL PPWTQNDLSV SLGPTIDAWP
NSDTLSHRID AMIRENPSAQ ALDDETSQFS YEQMGRRIDE IAASLTSAGL SENDFVGVFQ
ETGVDWICSM LAILKLGMTY VPLYPPIGMP RLAANVQVAQ PQAVLVDDST ADKFDRLGTQ
SAQMIHVPIA GSSTAEVPIR AKSGQKAMIL CTSGSTGIPK AVVHTNRSLK ALVEPHAIVQ
EQDKPSYAAR VLQQSAFSFD LSIDQTMLAL CNGGCVIVVP NSKRGDPLGT VDMIARHNIT
YTMCTPSEYS IWHRFARDCL LDCTAWENAS SSGGPLSTAL VRAFAGLELP HLRVFNHCGP
TETTVTNRIE LNFADYAEGD KAQMRYVTDV GFPCANYSTY IVDENMSLVP RGYPGEIVVG
GAGVADGYLG RPDLTKEKFI QDPWTSSKEW KIMYRTGDRG KLRANGMVDI LGRIEGGTQV
KLRGYRIELD DVESAILSAA QGVLSDAVVT LRYPEERHED HYDDGFLVAH VVVADKSLRR
PEVESFLRKI VSKLPLPHYM LPALMLPIDR FPLTAHQKPD RNAIAALPLP AFTLATANDA
IAEEGSLESE TQKKIAKMWR TLVPASASAT ITADTDFFHV GGSSLLLIKL QGMIRKEFNV
SLRLLNLMAA SKLREMAALV NDEVSGGDID WERETKIPDE WLSIPQVASQ KADGSLRVLV
TGATGFLGQN LMSHLAEALR VSEVHCLVRD TSIDEASDKV TLWHADLSQP NLGLSDTDFT
RLSDRVDAII HCGANRSFWD DYRSLRAVNV TSVAELIRLA LPRRLPVHVL SSGAVKRYGD
GHPPVDGGDG YVASKWAAEG LLRDAAERTG LPVFIHRPAP ALTATETGDE DTITSDELLR
LAKAISLRPD PTGLNGTGHF APIDQISSRI LDALLQSSVQ SQDDVNVIEH AGTKTLSMGE
FANLCEQLPE LKELPTTKVL QWFGQAKKQG LKQFLTALEV EFSDDKGDAA VMSR
//