ID W7Q057_9GAMM Unreviewed; 956 AA.
AC W7Q057;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Protease 3 {ECO:0000256|ARBA:ARBA00017565};
DE EC=3.4.24.55 {ECO:0000256|ARBA:ARBA00012449};
DE AltName: Full=Pitrilysin {ECO:0000256|ARBA:ARBA00033450};
DE AltName: Full=Protease III {ECO:0000256|ARBA:ARBA00031184};
DE AltName: Full=Protease pi {ECO:0000256|ARBA:ARBA00029597};
GN ORFNames=Q427_10100 {ECO:0000313|EMBL:EWH02185.1};
OS Halomonas sp. BC04.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1403540 {ECO:0000313|EMBL:EWH02185.1, ECO:0000313|Proteomes:UP000019279};
RN [1] {ECO:0000313|EMBL:EWH02185.1, ECO:0000313|Proteomes:UP000019279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC04 {ECO:0000313|EMBL:EWH02185.1,
RC ECO:0000313|Proteomes:UP000019279};
RA Farooqui S., Greene A.C., Patel B.K.;
RT "Draft Genome Sequence of Halomonas Strain BC04, an Aromatic-degrading
RT moderate Halophilic Bacterium.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endopeptidase that degrades small peptides of less than 7
CC kDa, such as glucagon and insulin. {ECO:0000256|ARBA:ARBA00002184}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWH02185.1}.
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DR EMBL; AZQX01000117; EWH02185.1; -; Genomic_DNA.
DR AlphaFoldDB; W7Q057; -.
DR PATRIC; fig|1403540.3.peg.1898; -.
DR Proteomes; UP000019279; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000019279};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..956
FT /note="Protease 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004900330"
FT DOMAIN 73..188
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 233..409
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 417..688
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 692..867
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 956 AA; 106988 MW; 79B37A22A4A530B4 CRC64;
MSSLATYRQA QRPWPVPLAG LLLAGALFST AVAAQPTEQS AEAAVDDVVA PRVSPHDTRD
YRVVTLENGL TALLVSDPDA DRAAASMNVG VGSAQDPDDL AGLAHFVEHM LFLGTEPFPQ
ADAYQGYLRR HGGSHNAFTA PQDTNYFFDI EPEALTGALD RFSQFFLTPL FNPDQLESER
NIVHSEYMAR IRDDGRREID VLNQVLNPDN PTVGFSVGSR ETLDPPEGEA TLRQRVIDFY
ERYYDANVMH LALVAPHSLD ELETMVAERF ADIADRGLER PVIEEPLVLE KDLPLQLEMQ
SVRDSRHVRF MFPVPDPIQH YTHKPADYLA HLLGHEGEGS LLAVLREAGL ADGLSAGVGR
SDERDALFTV SISLTPAGAQ RLDEIEATLF AAIDQIRESG LDEWRYDEQA QLAEQQFRFQ
QHGSPLQGAM RLAMNLARFP VEDVQYAAYR MDGFDRELVM QYLDGLRPDR LLRLYSAPDV
EGAELSPWFN APWREVSADD PARAEPLAGL ALPEPNPFIA EDLTLLEAQH ERPSQLLDEP
SFALWHMADA SFNTPKAEWR ISLQHPAANS DPRQAALAHL LAGWLDDSLN EDFYAARLAG
HHAEAYAHAR GITLSFSGWR DRQDRVMQRT LTQLQQGEID EANFERARYR LQREWRNAPQ
AALFRQAHRT LTEALVRPQW PTDDLLEASR ALDVEALRDF RDAFLADLHM EALAVGNLDE
ELAIQEGRLM AEMLQPRAPK EAIPDLTPLR IEEGLPTLHP VTSREESLVL RYLQGSDRSL
ESQARLAVLG QVIDTPFYQR LRTEEQLGYV VSASYSPLLD APGLSLLVQS PDTPSDEILA
HIDTFLDAFG EQLAAMDDDD LEAYRQAVHD NLLQRDTSLS GRTNRLWRAL SFGDTDFDRR
ERLAARVLDV SADELSQAWP ELREAAIATI SFDPGDEPSD VANLTQHLAP MPEADD
//