ID W7Q737_9GAMM Unreviewed; 774 AA.
AC W7Q737;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Q427_21595 {ECO:0000313|EMBL:EWH00054.1};
OS Halomonas sp. BC04.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=1403540 {ECO:0000313|EMBL:EWH00054.1, ECO:0000313|Proteomes:UP000019279};
RN [1] {ECO:0000313|EMBL:EWH00054.1, ECO:0000313|Proteomes:UP000019279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC04 {ECO:0000313|EMBL:EWH00054.1,
RC ECO:0000313|Proteomes:UP000019279};
RA Farooqui S., Greene A.C., Patel B.K.;
RT "Draft Genome Sequence of Halomonas Strain BC04, an Aromatic-degrading
RT moderate Halophilic Bacterium.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWH00054.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZQX01000253; EWH00054.1; -; Genomic_DNA.
DR RefSeq; WP_043516398.1; NZ_AZQX01000253.1.
DR AlphaFoldDB; W7Q737; -.
DR PATRIC; fig|1403540.3.peg.4045; -.
DR OrthoDB; 8553030at2; -.
DR Proteomes; UP000019279; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019279};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 223..271
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 292..345
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 377..516
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 525..774
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 774 AA; 86867 MW; 2B10322BF399E8F4 CRC64;
MPVLPSEERL ESLGAPLPVS PQRRQLVQEQ VHLLYERLWQ PVLASVMGAC LLVAAMWPLL
PATLLVGWLA ALVFVSCSRL GLAWYYQRLS ASRRRQRRWL YRFAWGAGIA GTVWGAAGLI
MFTMEHPGQL AALAIVLAGV TAGGMTTLSS VWWVAPIFIL PTMLPLLGQL LLYGTSFAWL
LSAMVVLFLG LLLTVSRRLY RIISDNIALR LAVTSRETQL RESEGRYRAI FRHTPLGVMH
FDREGRVVDV NEKCLDILGA SRQRLLGFNL LEQVEDKRVS SAVSQALVSG TGYYEGTYRA
IVSGKLTPLR AFYNALRNEK GDIVGGVALI EDFTERKRAE EIIHRQAYFD PLTELPNRRL
LIETLASTIR DRRDDGRLGL VMFLDLDRFK MINDSLGHAV GDELLRQLSK RLLVFMRDGD
MAARLSGDEF VVLVPALSGD RQAELVRAEQ MARDLLTSLR KVYDLEGHRI SVTPSIGYTL
FPLSVDDDVG DVLRHADTAM YQAKVKGRAQ VCGYEPAMQT QITWRLEMEQ ALRRALTEDQ
LLAHYQPQLD QDGRIFGVEA LMRWRHPVHG WISPEVFIAI AEESDLIVEL ETWMLDNCCE
LLTRLPAETL PRLSVNISVR HFTQPGFVEG VTWVLGTHGV DPSRLTIELT ESIMIDGLGD
AVERMHQLKR LGVNLALDDF GTGFSSLTYL KCLPLDELKI DRSFVSDLDS DSNDAAIVET
ILAMAQHLGI EVVAEGVENA AQLDFLLNRG CRRFQGFHFH RPMPGTALER LLSD
//
