ID W7TRE5_9STRA Unreviewed; 586 AA.
AC W7TRE5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=Naga_100002g79 {ECO:0000313|EMBL:EWM28757.1};
OS Nannochloropsis gaditana.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Eustigmatophyceae;
OC Eustigmatales; Monodopsidaceae; Nannochloropsis.
OX NCBI_TaxID=72520 {ECO:0000313|EMBL:EWM28757.1, ECO:0000313|Proteomes:UP000019335};
RN [1] {ECO:0000313|EMBL:EWM28757.1, ECO:0000313|Proteomes:UP000019335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-31 {ECO:0000313|EMBL:EWM28757.1,
RC ECO:0000313|Proteomes:UP000019335};
RX PubMed=23966634; DOI=10.1093/mp/sst120;
RA Corteggiani Carpinelli E., Telatin A., Vitulo N., Forcato C., D'Angelo M.,
RA Schiavon R., Vezzi A., Giacometti G.M., Morosinotto T., Valle G.;
RT "Chromosome Scale Genome Assembly and Transcriptome Profiling of
RT Nannochloropsis gaditana in Nitrogen Depletion.";
RL Mol. Plant 7:323-335(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWM28757.1}.
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DR EMBL; AZIL01000274; EWM28757.1; -; Genomic_DNA.
DR AlphaFoldDB; W7TRE5; -.
DR EnsemblProtists; EWM28757; EWM28757; Naga_100002g79.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000019335; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EWM28757.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019335};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 240..386
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 586 AA; 64925 MW; A4C63205EAE5EF80 CRC64;
MLGGWAKPCS VYVIICHTNA RSALLAATRP CLESPIAFMR EAREERVLLS LTLPRVLAAR
QAGGARRASA KFKRGLGTYG RHSFSFSHPS KGLFRPNIFT RLRQCDKYHT ILLMENGDAF
IDLISKKRVQ LVIKGGDPCI EVGGGLQVSL YDVIGSAVIE TQQSEGTKLL VYAYPRSVGR
QYPCGKVYPI AKRRPQYLHF MTPKAQLAKR WDQRIKELAW RESWLSRQDG LDGTHKSKRW
RQRRLLVVLN PAAGRGQSQA VYTSVVAPML EQAGVAHELV VTRKAQEAKS LMHNLNTEAW
DCVVAIGGDG LLSEIVQGLY SQDPVSCHPL TRLPLAIVPS GTGNGMAASF LYQQAEVPCP
INAMFLILKA KSTVPADLSL VEASDGQRMS FLALSFGLVA DVDLESEVIR WAGSFRMDLF
ALYAILRLRS YRARLSYLPS KEGPPPRAAA LPPLRARLPD ASGWVHMEHD FLMVLISHVS
HIAESAHSNP GKRMGDGTLQ ILVLRRQPSL SRLRLISLFL ALERGYHVTA DEVEIYNAVA
YRLESLTERG VYTLDGEAVP CGSIQGRILP QAMRILGSAV LERQEK
//
