ID W7TSS1_9STRA Unreviewed; 1640 AA.
AC W7TSS1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Multidrug resistance-associated protein 1 {ECO:0000313|EMBL:EWM30275.1};
GN ORFNames=Naga_100003g89 {ECO:0000313|EMBL:EWM30275.1};
OS Nannochloropsis gaditana.
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Eustigmatophyceae;
OC Eustigmatales; Monodopsidaceae; Nannochloropsis.
OX NCBI_TaxID=72520 {ECO:0000313|EMBL:EWM30275.1, ECO:0000313|Proteomes:UP000019335};
RN [1] {ECO:0000313|EMBL:EWM30275.1, ECO:0000313|Proteomes:UP000019335}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-31 {ECO:0000313|EMBL:EWM30275.1,
RC ECO:0000313|Proteomes:UP000019335};
RX PubMed=23966634; DOI=10.1093/mp/sst120;
RA Corteggiani Carpinelli E., Telatin A., Vitulo N., Forcato C., D'Angelo M.,
RA Schiavon R., Vezzi A., Giacometti G.M., Morosinotto T., Valle G.;
RT "Chromosome Scale Genome Assembly and Transcriptome Profiling of
RT Nannochloropsis gaditana in Nitrogen Depletion.";
RL Mol. Plant 7:323-335(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWM30275.1}.
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DR EMBL; AZIL01000038; EWM30275.1; -; Genomic_DNA.
DR EnsemblProtists; EWM30275; EWM30275; Naga_100003g89.
DR OrthoDB; 55934at2759; -.
DR Proteomes; UP000019335; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019335};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1026..1051
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1063..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1091..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1256..1277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 318..605
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 666..902
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1032..1315
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1381..1620
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 628..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1640 AA; 179564 MW; F2688DD12E449ACE CRC64;
MSYPSKRILL IIQAGLDATA VVILLILVLT SPRLRNSARP AIKTDKSRKP GSTATSVRAF
HGVALLLVSL GLWQALSAYT HASGVDVAAG LATLATWAFL SFLTYVYPPA PVRSYRGSEM
KPSMLQRGLD VVRKLVGVTS VPTAALVPVV ASERQWGPLV FFLVEALALG GQWILSWRIS
GMLTAGANAA CDISALQHEP LLSVVECSAH ESVETEGMAD KINLDEPEQL ESDASILSRL
AFWWITPLLS RGYRNKRLDA EDLPALEPGD RPATTHAALR REWARRAEIA RQRGRSLKPQ
GGWLVMRVLL AAQWRTFVVC GAVLTLATAL QLSVPVVLNR LLAHIEAGLL AKGGAGKGYA
LAVLLFALAV LQSVSEHQFW IWGVRCGMRA QSALMGECFR KALCLGPESR RKYSSGQLIN
LMSVDACRVA DVNVVPMVHW GTWCAVLTLT ISLVALHALL GASSFVGVII IVVFWPLGYL
LGLRGKKAAM HIQRERDNRA SVMAEVLESI RLVKSLQWED FANSIIKQAR QREVKAQIQR
SACFGGNNAL AQLAQVMGPL VSFACRILWE KEPLTAAVAF TSLAWFNLLK RPLNCFPSAL
TSFMDCLVSW ARLEELFLSE EVSALQPPED AAPHNALENS SSTPSVALSP LSPSVPESCV
RRALAVEMSE CSFAWTREGN ESPPTLQDVT LRVKAGEFVV VVGPVGAGKS TLLHSLVGDT
IQVKDVPGVR WAVHGKVALV EQTPWIQNTT IRDNVVFGAA LGYKQDRFRE VIRRCGLLQD
LQGLAVQGGE MMEVGESGIA LSGGQRQRIS LARALYSDPD ICLFDDVLSS LDVSVGRRIW
DECLVDFLRG KTRVVVTHQT HFIHHPAVDR IVVLDACGRL RASGVYNELV ASEDQQVVDA
VLAHDNSDGR RTGVGPRRDV PLGSSHALHL VGEEEEGRHE TLEGGLGAKS HFSFAERRIE
GGLAGSTDGG ECAGEIEVDS EKGAWGPEEY TGMKVQAFND WEERRQGGIE PRLLVMYLRR
FGGFDSLTFV GFVLGLLITE QACNVLQWFW LSHLTGAESG AESASIQAAE VTALIGLGAA
LCVITTVRIL VLIFGAVTAG NVLHGAMLRA ILRAPMRFFD RQPSGRILNR FIADQAAIDG
IVPSTLADFF QQLLYFGATL AILCYALPEM LPVVVLLAMP YRAISQYYRW PARDLRRLEA
VSKSPVNTQY GETVRGASTI RAFGAQERFF HAHLALSTRS IQSYWIKWVA NQWVTIWLEM
VGTLFMLFCG VLAVWVTGPQ APEVLASHID GGKMGLLMSY AVLVPNNLGW LLKVYFMAEI
EFISVERVFQ YVRLKPETSL VGKASDCGQV NAENGTSEGE SSHVSAQKEP AALPLPTAAG
VEGHEIYLCY GERGSSPTLR GFCLGVRAGE KVAIVGRTGA GKSSIFQALL GFYHVESSKS
FAVEKVEVSR FSLKSLRHWV RLIPQHPTLF GTTLMDALVG REAMEGKEMQ AREAEVWQAL
EAVRMAQSVR ALPRGLDTRL RTLEFSEGER QLLCIARALL HLAPVMLCDE VTSAIDLKTD
AIIHKIILSL PCTVLWICHR LQHIQDFDRV LVMERGRCVE EGPPAVLLGD VRSTLSGMVR
KCELGLTPRV FREEEWTSDP
//
