ID W7X443_TETTS Unreviewed; 772 AA.
AC W7X443;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Kinase domain protein {ECO:0000313|EMBL:EWS74085.1};
DE Flags: Fragment;
GN ORFNames=TTHERM_001424459 {ECO:0000313|EMBL:EWS74085.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS74085.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662668; EWS74085.1; -; Genomic_DNA.
DR RefSeq; XP_012653378.1; XM_012797924.1.
DR AlphaFoldDB; W7X443; -.
DR GeneID; 24442336; -.
DR KEGG; tet:TTHERM_001424459; -.
DR eggNOG; KOG0581; Eukaryota.
DR eggNOG; KOG0597; Eukaryota.
DR InParanoid; W7X443; -.
DR OrthoDB; 180102at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00180; PKc; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR027038; RanGap.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24113:SF12; F-BOX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24113; RAN GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF13516; LRR_6; 8.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EWS74085.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EWS74085.1}.
FT DOMAIN 164..444
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EWS74085.1"
FT NON_TER 772
FT /evidence="ECO:0000313|EMBL:EWS74085.1"
SQ SEQUENCE 772 AA; 85836 MW; A2EDE126FEF394AA CRC64;
MFSLGLVLLE LDNIQTFDFT KTTNQQKFEI QLGNIFSSFQ INRQSQIYRI VKQCIEFDPK
NRTPPVDLLI QFIVQNQNYL DVEISSILNK KQLLKKAEQL TQIQKSVVEK SKKQEIELLQ
ISQIYKDQKF EMLIQEFKQL KEKPFEIFEY QIILDLLLKN TQYDSNFEFI SVGATGLILG
VYNKSYKRHS ALKIQRVSSK HEIVREIGII RDCQMPLVIK FYGFFYLDVT KKEDFVVYEI
EKCSGNLKQY FNRLKKDKIQ LNDEEKMQIA IQVIDVINYL HYNDIVHRDI KLENILYIDD
NQSQVPIIKL TDFDQARKMH YELIQINDDI LKDYKSIKGA CGTLGYISPE IFNTLLYTFQ
SEIFSLGVTL AVIDNFETLE PYLKQKNLDY LHGFKIPFEP SHLVTNELIK RNTKIYDIIL
NTVVFNQEKR KDLYSIMADL HENYGYQFYS KEITFFQNIP SHFVYCKIAS FVLSNNIGPD
GAKAVASEIA KCPTLSTLSL YLQSNNIGPD GAKAVASEIA KCPTLSTLTL DLQSNNIGPD
GAKAVASEIA KCPTLSTLTL GLDDNNIGPD GAKAVASEIA KCPTLSTLSL GLYDNNIGPD
GAKAVASEIA KCPTLSTLSL YLQSNNIGPD GAKAVASEIA KCPTLSTLSL GLQSNNIGPD
GAKAVASEIA KCPTLSTLSL CLYDNNIGPD GAKAVASEIA KCPTLSTLSL YLQSNNIGPD
GAKAVASEIA KCPTLSTLTL GLESNNIGPD GAKAVASEIA KCPTLSTLTL GL
//
