ID W7X5I6_TETTS Unreviewed; 1029 AA.
AC W7X5I6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Minichromosome loss protein Mcl1 middle region domain-containing protein {ECO:0000259|Pfam:PF12341};
GN ORFNames=TTHERM_000420919 {ECO:0000313|EMBL:EWS72657.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS72657.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662536; EWS72657.1; -; Genomic_DNA.
DR RefSeq; XP_012654825.1; XM_012799371.1.
DR AlphaFoldDB; W7X5I6; -.
DR STRING; 312017.W7X5I6; -.
DR GeneID; 24438882; -.
DR KEGG; tet:TTHERM_000420919; -.
DR InParanoid; W7X5I6; -.
DR OrthoDB; 3686044at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR022100; Mcl1_mid.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19932; WD REPEAT AND HMG-BOX DNA BINDING PROTEIN; 1.
DR PANTHER; PTHR19932:SF10; WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1; 1.
DR Pfam; PF12341; Mcl1_mid; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 478..768
FT /note="Minichromosome loss protein Mcl1 middle region"
FT /evidence="ECO:0000259|Pfam:PF12341"
FT REGION 326..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 796..823
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 346..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 118886 MW; 37A0ED0F314158BB CRC64;
MSAVYTTHKI SNHLGRFGFD FYENEKKLVS AGQDCVFKLY DIQDGDFKQI KTYNCEDVFD
LSVNQANNDI YLGYYESKNL IKVNDIDNID EIIGEEIASF TGPVYNISIS NKQKFIGVST
QENKGYLIKL NDNGTLTQRY LNDNHVGSCL FTTVDQEGEY ALTIGCDGNI HIYNVKNFET
SDAVFETQLH VTVTMVTEKE YVMQCSFNEQ HQIALGGNQS LQLISRDENG KWILTRIPEI
NHQRDIQICQ WVDGQSKYLI TAGIEKDVKI WNVQEKLCIG VVNCEENICS IRYSKVNKAL
FIGDTEGNLY RWNDLDFEKM TETAKANQQT IKQQPISKHK ESSEITQNQK FGTPQEKSAQ
SSKEDAIKKQ KYALLMEEED DQIESHTKSS VVSDTKMSTE IQESKVDQKQ LKKKNQNLLE
SLQEEKIKAK ELPQVKEKIA KNEPVQTPTK EMSTLSINES EQQQKRHKKN LKIQDIIYPS
SVSKQLNRSC ILWNLVGQII LREEDRNLFL EFDFPDKEFH SRITIKNLHN YSMAAMNRQG
FILASKAINS SQEYESEEDF ERFDFHQDAY SYSCIYFQSL SKSDKTLWSL KLGQDENVET
VAIGDGWCAV QTDLQYIRIY SFSSMEQHCF CIDKPAVCIS GYKNILAIVY LEGEPIYGCQ
SIKLKFFDVN SGEMIKEIGV PLTPFTTLTW FGFSEEGLVL TKDSKGVIRA LIGYSNWTPI
YEQPHNKNFW LKGMVDYKLA GFLLPKDELE PRLTQIYHEK CFDMQLPLPT GDYFEQNDDY
KSMRHNQLIL KHEQYRYQNL EQNQKLEEKV KALQKDIDVK VLRLFQHCLK YDEPQKALQI
VKNNLINLLY IDSCIQIAQK LKLKQLISDL QQLQQDKESQ SQFIQSIVQA QMKPHQKNLI
IVSQSEKDHL KLKNSNKLVI SNTKNNGLDS EDEEEEDSKG QDDLHEQENK KQNSESKNGS
SQKQGQAQNQ VEKGIQIAEK KIIGNNPFQK QTKQTVSVEE GLFSVNNKKR KDENLLNQKP
KESNKKLKF
//
