ID   W7XFS8_TETTS            Unreviewed;       506 AA.
AC   W7XFS8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Sodium/hydrogen exchanger family protein {ECO:0000313|EMBL:EWS72871.1};
GN   ORFNames=TTHERM_000933179 {ECO:0000313|EMBL:EWS72871.1};
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS72871.1, ECO:0000313|Proteomes:UP000009168};
RN   [1] {ECO:0000313|Proteomes:UP000009168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
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DR   EMBL; GG662564; EWS72871.1; -; Genomic_DNA.
DR   RefSeq; XP_012654599.1; XM_012799145.1.
DR   AlphaFoldDB; W7XFS8; -.
DR   GeneID; 24441134; -.
DR   KEGG; tet:TTHERM_000933179; -.
DR   InParanoid; W7XFS8; -.
DR   OrthoDB; 180563at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF191; SODIUM_HYDROGEN EXCHANGER; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        25..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        258..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..349
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   COILED          412..456
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   506 AA;  57187 MW;  1C845FDB4AD90E9B CRC64;
     MLPPIIFSGG YTLQNKNFFS NFGYISLYAI FGTLIGFAVI LLLTIAFLNQ GMITDLNNNT
     INLTAKDILY FSATMCSSDT IAALALISSK TYPKLFSVVV GEGLLNDAVS LILFNSISKI
     VNSNGEAQLS STTFWSLIFY FIKSLVLSIL IGIFVGLFAT YITKVYRPLM QDPVKVNIFL
     LAIGYMSYCL GEIAGVSSVI SMLGSGIVMN HYMKHNMEEE SLKTTTVTIS TISSITESIL
     FIYLGLSSWS YIGDKSKISY SFILLGFLMT LIARFGCIYI TSLIAKTIMK IKWGLNKYEL
     LIIWFSGLIR GAVAFALIIN VENQLNPVVT STVLFIVFFT TILLGGFMQS FIKKTTQTME
     NSLKVKENNL VLLGIEIEKR KLKTVYNASI FRLLEDGFLK SKFIFDYPNK QKIFKEEKKK
     RLQQRIEEYN QLKLSIQQYK QQNEIVKSNQ NNLDQSLQNG INNLMLTQAK ECGQNYNVEF
     ADNYKISTTD TQNKQEIDQY QIENKL
//