ID W7XI56_TETTS Unreviewed; 1735 AA.
AC W7XI56;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Amylo-alpha-1,6-glucosidase {ECO:0000313|EMBL:EWS74331.1};
GN ORFNames=TTHERM_000128319 {ECO:0000313|EMBL:EWS74331.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS74331.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662699; EWS74331.1; -; Genomic_DNA.
DR RefSeq; XP_012653152.1; XM_012797698.1.
DR SMR; W7XI56; -.
DR STRING; 312017.W7XI56; -.
DR GeneID; 24437398; -.
DR KEGG; tet:TTHERM_000128319; -.
DR eggNOG; KOG0998; Eukaryota.
DR eggNOG; KOG3625; Eukaryota.
DR InParanoid; W7XI56; -.
DR OrthoDB; 1427975at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0004134; F:4-alpha-glucanotransferase activity; IEA:InterPro.
DR GO; GO:0004135; F:amylo-alpha-1,6-glucosidase activity; IEA:InterPro.
DR GO; GO:0005980; P:glycogen catabolic process; IEA:InterPro.
DR CDD; cd11327; AmyAc_Glg_debranch_2; 1.
DR CDD; cd02859; E_set_AMPKbeta_like_N; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR010401; AGL/Gdb1.
DR InterPro; IPR032788; AGL_central.
DR InterPro; IPR032792; AGL_glucanoTrfase.
DR InterPro; IPR032640; AMPK1_CBM.
DR InterPro; IPR032790; GDE_C.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR10569; GLYCOGEN DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR10569:SF2; GLYCOGEN DEBRANCHING ENZYME; 1.
DR Pfam; PF16561; AMPK1_CBM; 1.
DR Pfam; PF06202; GDE_C; 1.
DR Pfam; PF14701; hDGE_amylase; 1.
DR Pfam; PF14702; hGDE_central; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 264..689
FT /note="Glycogen debranching enzyme glucanotransferase"
FT /evidence="ECO:0000259|Pfam:PF14701"
FT DOMAIN 855..922
FT /note="AMP-activated protein kinase glycogen-binding"
FT /evidence="ECO:0000259|Pfam:PF16561"
FT DOMAIN 941..1188
FT /note="Glycogen debranching enzyme central"
FT /evidence="ECO:0000259|Pfam:PF14702"
FT DOMAIN 1267..1720
FT /note="Glycogen debranching enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06202"
FT REGION 33..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1735 AA; 201395 MW; 178F7FCDFE9B5D39 CRC64;
MIYNAYQQYL FKYIISNQQK IFIVSSIQHL SKQNKTKNNN KKIRHKLTSK KTNKQTQSYY
TNLKAQQIFE IPIKELQILK TRTQSSTQII QKIDKQQVMS TTNGVHQQHR TGQQFIVYLD
QNGSFPNSHE KQYIVHANDS VTITLDSSWL EQKTPILLTN YPEFDKTKNS YIHPIAPEIT
ESSSMTIQES ELLKKYKIFT GFYNSEGSWQ VDLQIQDFDG SLFLQVIFIQ GDYLPGQREP
LTIKNFGAPE WLMIQPRLTV NKNQIGMDQI IIQTVLPFSL GHSSKWLEIL RTQTNLGYNG
FHFPPIQKLG FSGSYYSIND QLKPNPDLFD QNEKEPFAAM KQIVNTIETE MNALSFVDIL
LNHTSFDSEW LLQLPEAVYN PENTPQLAVA LQLDEAIQNF SDKLATHQVK EYYNGSNRIE
NEEQLSVLIE IMKTKIFYGM KLEEYFLLDK QAISTKFQEA VKGKGLKLIQ KEQDVDDDEN
IFSRSGFDIL NAFIKQNTSS LGSKRYGATL DINKLIETEI SKQPTLFSLE AFERALTHFN
QTWMDRFYEY TNQAVESTRG QIRYWHIDLG RFEVTNQYSL VPRYFTKMSN GRYAANNGWI
MNYDPLKNFA DDQEFHYYRR TICIWGDLIK LRYGSSKKDS PGLWKRMKKY IQEMAKVFHG
FRLDNAHSTP LHVGEYFMRK ARNVNKNLMI FAELFTGNGE KDAIFCKRMG INALVRELNH
NRNPLDLYHN LHWLSRSQES SVGSLPRLFQ FDFNSNQKKT HLVPTQTKSI VYDQTHDNES
TLSIFSHQQT VPLIALTSFS HFVQGTVRGF DELYPEKLSV VSERRKYQSQ LDCTQTELDN
IPIEVGIVAT LKFSTESIEI KGSWDNWTTG IKMNHHSGNH ETGVFQYLAK FQVPSANTSY
EYKYIIDGKW IADETKPIKN ENNYFDVPEN ANNLTYYNNL CLLRKTFIEI NQTLNKHYPF
IFYSHYDYGF LSVMRETYQK DQYYFLISRT ALCENDSKVN VEIECPGIIQ SIEGIYSASD
SIDVDGNRVK NHEILTGLKT KIYKEFNLFK YGELKFNQQT MKHTIHFFNA PPSLSIVIKC
TLHATQKQGI ERLNYMLHHI QDDEILALYR PLKTEDINYL FFSSEQEEHE RSGYGMFNIP
NKGNLLFGGL AGVFKDVNEA CLYNDLGKPL FVNLREGYWY LDYIINRLNK YEGNLTQITG
YIQSYFDLLK VIPKYLIPHY FSQFILQIQL HAHKITASKL KGEALKLSSS FHKNLLFANY
QFLSVLPSTH FDEYSLSMAA GLPHFTTGWA RCWGRDTFIS LRGTLLIPGL YEEAKSIICM
FASTLRHGLI PNLLDNGKSP RYNCRDACWW FVKGVKDYIQ FTNDTQILKK EIKMRFLSDD
FMEHYDKESK GQVKKMLLQD IIFEIFQKHA KGIHFREWKA GWEIDSNMDT EGFNIHLKLD
EVTGFIFGGN MRNCLTWMDK MGSSTKAGNK GIPATSRDGA PIEMTAILKC CLDFVNSCPD
FPYKEVETAS GKKLTFRQWG SLISANFEKC YWIPNKLPSM DNMSDKLFKY ITRKGIYKDL
YNSSIPRCDF QLRPNACIAI ALAPELFTPQ NALFHLATVE GVLIDQNSLG VKTLDKLAQE
YVPYYDNSDD GIQPKTAHGF CYHNGPEWVW MYGYFLKALL EINRKVPQFT KEKLMSYLAN
HKRHIIKSEW LSLPEMTNQN GEYNNFSCQS QAWSIATLVE VCYDSIQLPV KTLAK
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