ID W7XKQ6_TETTS Unreviewed; 2788 AA.
AC W7XKQ6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=TTHERM_000549649 {ECO:0000313|EMBL:EWS76726.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EWS76726.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662864; EWS76726.1; -; Genomic_DNA.
DR RefSeq; XP_012650719.1; XM_012795265.1.
DR STRING; 312017.W7XKQ6; -.
DR GeneID; 24439525; -.
DR KEGG; tet:TTHERM_000549649; -.
DR InParanoid; W7XKQ6; -.
DR OrthoDB; 181147at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF12; ADENYLATE CYCLASE TYPE 3; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1229..1250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1262..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1318..1340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1360..1377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1384..1401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1421..1438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1531..1551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1563..1583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1634..1652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1678..1695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2386..2404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2410..2432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2444..2466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2478..2498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2532..2551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1754..1888
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 2603..2735
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2788 AA; 327209 MW; 39D584247BD76F64 CRC64;
MQNRQTFQNQ IMQSFKQSKK KKEKEEKEDE NQRVYSRKLE LVNGELFGKI QVISDKICTT
NKISFFKKDR YVIFNFLLML SKNYFYRFGN TACIVIVFIF LGTPVKNMIK SRLTYEINDY
IYFYLLQSVI GFIVLLIRDL YIITNLQGLL SQINQSQYTL FQKFNDDKIQ QLIKSSRDDE
DDQYKQKIAT YTSSEVSNIQ IGDIVLLKKG DICPADCLIL DMKEQFCSVK NNVCSESNQF
DIKRAPQVTQ ILSTSKIKGF HFEYRKILNG IVEFVSSTEN ETQFEGYIKL NKDPNGENLN
DQNMIFRGQE LMYTEWCVAL VLYVGYECRF FKIYSEERKK IKFAKGNLSN KIEKFFLFTF
LFIILFTLAS SIIDYTQPFN SKFNSTQIDQ NTGQVAATYF IEYIIFLPIV LYPFYDIMHL
TYLYMKKRVF ENPFQFFPCQ LDIKKDEDQN NEDLQEINLQ ESAFTPIDDI QDSEMCLSTH
AVFSKSGTLT HNEEFQLASI TIGNKMYKLN IETLTNVINH IAAAKPSLQY VQENKVPSYE
AIDIDEGTIN NSPDRKNVCT RKQNLEKMQA NDFDLMMLRN VFVQNVQNQT LNTQSTQQQN
EETINTNEAR EQKYKKEYLD TASPLNGNGS LEKNTQINQQ IDASPILHHR SDIGRMFSSP
KSNISGDFLN EPDYINLRGQ TISENQSMES SPADVHHKFE NVLVRQKNES CSMSQSGIHL
DISNFTGGIE KFYKNTQQNS QFTIEGLLDS QAPLDFSSSI NNSKIGQNSF EKNDIEFIQE
ERDFLKDLLK NDQSFANAIK AISVSHMTKT KFQQTQLQFF QETINPLDKL IQDFTSQIGY
QFRCSNKIND GGKDKFQYIF TNYQNETKKY TLLLPPAYNE RKTRFCIILK EDDSKRYTLY
LKEELVNYPS YMMVDKGINR QDQEKRLRRL IEQGQIPIAF CKRELDELEI YQIQNQYENA
LKAPEFYQNK EAIINYIYSS YIFKLELQCI IGIQETLRKD SQELVSLMNE SFINTWMLTG
DQFQKAVPAA YNCRILQRES TQQTLIFDCN SYKNLKALIK NYIIILKQKY LGETPQINKN
QNDFQIQNSL KRKKTSFTNY EKEDNNKIFN IIISGKTFEI IQKNQYLNDH FTFLLFFTKN
LVGYQFDQFQ KAQILQNLKK CQPKSKILGI GNGLSDLRMY AQCDYSIEVV DFQKREIYAR
ANSIVRSMKD IIKQLAINSK INYLFREDLI IIIFKKCFLL GLLMFFWNSY QSSYGIQLFD
QIYLFQNIYY TPMAIFLLLM LKMYKWQQPF KKEIIDKVQT IIYIIHNKSA KRDNIIQYIK
TVFLQGTIDG LLLFLVNIFQ YQRSFISNNG QVLDQKFLDY FLYQNFHAFL IYKYLSYRKL
NWKIWIIAII SICLIQVNRI WDKDIQAQSF VVVNMTQVCQ GFLTISINLF TLNFYPLFQT
KISKQSKKFY ELFEILKNLL LEKPIKKFNL HMTKVIRNVF KDREKERALE ELITDDATIS
QSKTNPFTLK FLQKETETKY IQMISQRDKR FMQIYIILQI LLQYICQALM YSYELQDNHT
FNSFSICSAI LAITWFITLT SIYSKYFLQI NNFIIFIKVL CNLDLILSGK YVQNSLQEII
NHLIISQQSY VNPIYYIAAI MTTTLTFIFA FFKKYNQFEY FNEQNLETSY FITQTNQYIQ
STVLVFQVLI VILIIKNKYR FDHLQRLHFQ KLNHLSYETK KIQGVLSILM PKFIRDKIDK
NGEVQLQEDQ GEVSILFCDI CDFEQILSAE QENIVRLVDK LFRSFDSLCN HAGLQKIETV
GKTYMAAGGL KDSENKKSQY KQINPVARAV IMSFEMMDII KQFNYGDNEK VKIKIGIHYG
RVIAGVIGCH KPQFSLIGDT VNTASRVCST GDVGQITLSE QAYDEIKQIP YIIFQKKRVY
AKGKGDINTY QVMKRQKQKN QNSNEIPLRD QVIQRVSQKK NSEKGFINQL SEMSNKNMRK
NKTTILKQRK ILNEYHSQEN IEYFNSFNFQ LNSPTKLSEN KKYNIKIPDQ LTANRQQQQE
EGGTTNFEEM SSYKFAIQSN NLHTINGFAQ SQKSSNNNIL SKPFLSNGAL TKAFSSKVLG
NQGEAIQEAD EEEDKKIEAH KKSQEQFIEE RKKSEISQNL QDQQRKITTS LNYQINNRNY
NSPSIENKNN IEQSTIKEKV DIYTKLDCQN KETVDEDICQ QILRKQSKFK NEYEQTPQSE
TNTLKNHNLQ TYELISPIEA QKTVTIDEQA VTQENQIEQY DLNNLKRQDR KSKRYLSKEL
SKMWNQKIDN PESSTIIIQP IKALEQELGT DLKIDIIQEV KEAEVEIEKL DELFVEEKIL
NKKLGKKNHS EHSYQYNEFL KIDDYFLKVF LQHQIHINSN VLKRTLILSI MMAIFKSVCI
ILVLHDFTDF LYFCIILYGV SITICLAMLI IQKKKIFKIN GYKISIILSF IYYIQSASVF
IEILLMKLND QETEQYPPYI HVLTLPLIYL FILFLRVCMF TPRTMIFKAV FQIIVWNIVA
NKVCKMTIHL EYLVLFTIFI QLIIQINNFY LEISQFQYQQ TLESRAKKQN DILMYLLPEH
ILSKFLNNPN KKIDLIDQLD NVTFLFADIA GFTKYSGSVQ PENVVNMLRI LFNEFDQQCQ
KKNLYKIYTI GDCYVVIGTK NASNRLRPHE EAKNVVELGF EMIEIIKKVR SIVQFEELEM
RIGVHTGSYI GGVIGTDIVR YDIYGPDVMI ANKMESNGEQ GKVMVSKTTM NLLYDHYGSR
YNFTKGNEVY IKQFHKHIEG YFIEQNII
//
