ID W7YMK5_9BACT Unreviewed; 865 AA.
AC W7YMK5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=JCM21142_124665 {ECO:0000313|EMBL:GAF05906.1};
OS Saccharicrinis fermentans DSM 9555 = JCM 21142.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinilabiliaceae;
OC Saccharicrinis.
OX NCBI_TaxID=869213 {ECO:0000313|EMBL:GAF05906.1, ECO:0000313|Proteomes:UP000019402};
RN [1] {ECO:0000313|EMBL:GAF05906.1, ECO:0000313|Proteomes:UP000019402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 21142 {ECO:0000313|EMBL:GAF05906.1,
RC ECO:0000313|Proteomes:UP000019402};
RA Starns D., Oshima K., Suda W., Iino T., Yuki M., Inoue J., Kitamura K.,
RA Iida T., Darby A., Hattori M., Ohkuma M.;
RT "Draft Genome Sequence of Cytophaga fermentans JCM 21142T, a Facultative
RT Anaerobe Isolated from Marine Mud.";
RL Genome Announc. 2:e00206-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAF05906.1}.
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DR EMBL; BAMD01000153; GAF05906.1; -; Genomic_DNA.
DR AlphaFoldDB; W7YMK5; -.
DR STRING; 869213.GCA_000517085_00865; -.
DR eggNOG; COG3250; Bacteria.
DR Proteomes; UP000019402; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000019402}.
FT DOMAIN 589..863
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 865 AA; 99289 MW; 3F226D7F0BCBCBE5 CRC64;
MYVWVNGQSV GYSQGSKTPA EFDITPYLQK GPNTLAVEVY RWSDGSFLEC QDFWRISGIE
RDVFIYATPK TRVRDFKVNA GLSENYTNGV FSLELDIQSQ QKSTGLQASF QLLDGNKEII
QSSMPLKVKN HKANVVFNHN IKNVKKWSAE SPNLYRLVIS LKNKDNELIE TFGENVGFRS
VEIKDGQLLV NGQAVLVKGV NRHEHDPVTG HYISKELMEQ DIRLMKEYNI NTVRTCHYPT
DPYWYQLCDK YGLYVINEAN IESHGLGAAL QAPYDYHIAD DPAWEKPHLD RIERMYKRDK
NHPSVIIWSM GNEAGDGVNF VKAYKWLKSQ DTRPVQFEQA DNKRHTDIVC PMYATAEEME
NYARQTDIYR PLIQCEYAHA MGNSVGNLQD YWNLIEKYPA LQGGCIWDWV DQGILSKDKN
GNDYFAFGGD LEKPGTRNDN NFCINGLVSP VREPNPHIYE VKKVYQNISV TKGHRAGQFF
IKNKFFFSNL NKYNCEVSVL VDGKITHTSH FTDLNIAAQS TEAITVKLPE DSKKDVYVNF
SFVLKDDDGL LKKGHEVAKE QILIANAAPK VGIHAEGKLK VKESEKGWNI KTETSSLNFD
KTKGTFTNLS INGKEYIQEG PQPDFWRAPV DNDYGYGMVK KMGVWKEQDK KATVSNIEVS
QEKGMLTFKV SKRMEDVFGD FISTYKINGK GIIQVDHYIH FDPNRKTVSI PRVGSQIRLN
KDFNQTQWYG RGPHENYADR YTSAFMGTYQ STVDDMYYPY IRPQSNGYRM SVKWLTLNNG
AHGLKIEARN QLGIQAQYYE HDDYGNEPKK QAHHQYDMKK RDYIVLNLDY GMAGIGGDTS
WGATPHLIYQ LLRREYSWGY TITPF
//
