ID W7YY20_9BACL Unreviewed; 1428 AA.
AC W7YY20;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:GAF07324.1};
GN ORFNames=JCM16418_1334 {ECO:0000313|EMBL:GAF07324.1};
OS Paenibacillus pini JCM 16418.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1236976 {ECO:0000313|EMBL:GAF07324.1, ECO:0000313|Proteomes:UP000019364};
RN [1] {ECO:0000313|EMBL:GAF07324.1, ECO:0000313|Proteomes:UP000019364}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16418 {ECO:0000313|EMBL:GAF07324.1,
RC ECO:0000313|Proteomes:UP000019364};
RA Yuki M., Oshima K., Suda W., Oshida Y., Kitamura K., Iida Y., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequence of Paenibacillus pini JCM 16418T, Isolated from the
RT Rhizosphere of Pine Tree.";
RL Genome Announc. 2:e00210-14(2014).
CC -!- FUNCTION: Involved in some intermediate steps for the synthesis of the
CC antibiotic polyketide bacillaene which is involved in secondary
CC metabolism. {ECO:0000256|ARBA:ARBA00003299}.
CC -!- PATHWAY: Antibiotic biosynthesis; bacillaene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004789}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAF07324.1}.
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DR EMBL; BAVZ01000003; GAF07324.1; -; Genomic_DNA.
DR RefSeq; WP_052020075.1; NZ_BAZT01000003.1.
DR STRING; 1236976.JCM16418_1334; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG3319; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR OrthoDB; 9757538at2; -.
DR UniPathway; UPA01003; -.
DR Proteomes; UP000019364; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019364};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 425..501
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 544..920
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 1428 AA; 159815 MW; 1B099BD03FBFC1FF CRC64;
MRSLLREKAS LDMNVLAQSL QKLNHGLDVR AAFVTSSAHE LAEQLNGFLD SPSSSPARRV
YTTLDQQSPS RFVEAAEIRA ALADKELRYL AQRWVEGVTI DFEPLYRDRP SSWMELPHYA
FDHGVVFRFE EDTPVRGDRE VAAAISCDYD DPYLKDHKVN GDRVLVGAVL ASLAVEAFFH
KFEGHNEACI RKLHYLEPVI AKENQITELE AVTFPHDSSN DFQIAYRRSL AEEWKITAAG
QFQTPIAELT GTSKDIAGIR GLLDPVPSFN AIYERGEDIV QWGQLFRTLT QLYASPKELL
ARVVLNPDLQ VETKDYILNP LITNSAYLAM LYLVEETGIE GSFVPFGIHE IQVVRNKSFD
NGWLHIKLTK NSGEMLVFDV EAVNEDGETV VRCLGYSLKR SALRRVIQPV QDAFLPSANF
NHQDHVYRGI INYLVDKLAK SANLPTISDM EANLMELGLD SSSLLAMTGE IESATGIELN
PTLFFEYPSL RELADFFSTH HRESFIPLVE LARVPMKLVP PESKMTMMPQ SIECYSETGK
QHEHEGIAIV GMSGQFAECE NVAMFWEKQI EDRAGTRGID EKATQRVKSS RLKRSEELDY
TLFGISEEEA ALLDQQQYLL LTQAWKAIED AGIIPQTLSA KSTGVFIAHG KIESHSAAEQ
ESRPPQIDSP ASRMSNSVSY IFNLRGPCES YEADSSFFVA LNRAVQAIRG KECEQALVGD
VSLRSDNTGV ILLKPLEHAI EEGDPVYAVI QGTAVLHGGR GLSFNASSPT GMTDAVMSAY
QISGLNPRTT GYIEAHGWNP LSEDAAQLKA LADGYRQLIS MNASDLQEDV PRYVGTMAPI
SGMASFVKVV MALQHGVVPG TSGVGPDSAS TVVEDFSFLF REESLPWQVQ KNVDGGSILR
RADLNHSSPG GMNACVVLED YVPALMKPEA AADERGRSAQ IIILSAKTKE QLHDSARQMI
AYAQRPTRAA LSDAAYTLQV GRTPMEYRLS LVVTTWGDLI QSLLKYLESV STSDELRSSL
PIYEGRPMDD PTGFRSLLQG NLGETVYRTL YEERDYAKLA LCWAQGGEVS WQKLRKGEKL
NKIHMPTYPF VRITSLEQAP EKKRRVKTAT RPPVGESALD RPNGYPELLS LNRKIEGQPV
FWLHGGLGSV EMYQAVAGKS DRPFYGIQAR GYSNSRSPIK GIEKMASYYI EIIRSVQAKG
PYDLGGFSLG GMLAYEITRQ LQLAKEQVRT IVMIDSPFST LFKENKPSTK SLILQTINTM
LVSVAKDPKK MTETLINRNE VNMKVKDEEF LDEIIRFARS RGLSKTEAQI RSHIKKNIRM
QRAYEFEDYS PSPLPRPQEV SCYYLRNKSG IFLGSLEPFL TIEEDKVELD QTNYWGEWQR
RIPEFQLIDV EASNHMLMLM EPKAMSVITK FCEKIYSKAE AQVSLTTR
//
