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Database: UniProt
Entry: W7ZH53_9BACI
LinkDB: W7ZH53_9BACI
Original site: W7ZH53_9BACI 
ID   W7ZH53_9BACI            Unreviewed;       453 AA.
AC   W7ZH53;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 27.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=JCM19045_2932 {ECO:0000313|EMBL:GAF13674.1};
OS   Bacillus sp. JCM 19045.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1460639 {ECO:0000313|EMBL:GAF13674.1, ECO:0000313|Proteomes:UP000019372};
RN   [1] {ECO:0000313|EMBL:GAF13674.1, ECO:0000313|Proteomes:UP000019372}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 19045 {ECO:0000313|EMBL:GAF13674.1,
RC   ECO:0000313|Proteomes:UP000019372};
RA   Kudo T., Sakamoto K., Akinaga M., Kawauchi A., Nakahara T., Zhang X.,
RA   Yamada A., Oshima K., Suda W., Kuwahara H., Nakamura N., Nogi Y.,
RA   Kitamura K., Yuki M., Iida T., Moriya S., Inoue T., Hongoh Y.,
RA   Hattori M., Ohkuma M.;
RT   "Draft Genome Sequences of Cyclodextrin-Producing Alkaliphilic
RT   Bacillus Strains JCM 19045, JCM 19046, and JCM 19047.";
RL   Genome Announc. 2:e00211-14(2014).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAF13674.1}.
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DR   EMBL; BAWA01000016; GAF13674.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAF13674; GAF13674; JCM19045_2932.
DR   Proteomes; UP000019372; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019372};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019372}.
FT   DOMAIN        3     98       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      121    433       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      277    297       {ECO:0000256|SAM:Coils}.
FT   COILED      307    346       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   453 AA;  51478 MW;  6006AC243C696C01 CRC64;
     MAWSVSEATS YIKGLLEEDP QLMEVWIRGE LSNFKQHTRG HMYFTVKDDG SRLQSVMFAG
     HNRYLRFKPE NGMNVLMRGE INVYEPYGQY QFYVKEMQPD GIGSLHVAFE RLKKELEEEG
     LFDQAIKKPL PQYPAHIAVI TSQTGAAIKD IMTTLKRRMP RIRVTLLPVL VQGDAAPSSI
     AHAVEQASIA SIFDLIIMGR GGGSIEELWA FNEEIVARAI ASATVPIISA VGHETDFTIS
     DFVADLRALT PTAAAEMAVP DYREVLNQLE AMKHRSIRSI SEKLRTEQKR LETLNKSYAF
     RYPRQLVEQK EQQLDYLMER LSRSIKKELD VKRQALTRSN QALLRNHPHN HVTQLKSESH
     YLKKRLVKAM EIEMDRKKRE MGSVLSKLQL LSPLTTMERG YSLAYKEEKL IKTISDVDVD
     DEISVTMQDG RIYTKVTGKA INTSGGGWNG SKS
//
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