ID W8F091_9BACT Unreviewed; 802 AA.
AC W8F091;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AHJ95971.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:AHJ95971.1};
GN ORFNames=Hsw_0376 {ECO:0000313|EMBL:AHJ95971.1};
OS Hymenobacter swuensis DY53.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1227739 {ECO:0000313|EMBL:AHJ95971.1, ECO:0000313|Proteomes:UP000019423};
RN [1] {ECO:0000313|EMBL:AHJ95971.1, ECO:0000313|Proteomes:UP000019423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY53 {ECO:0000313|EMBL:AHJ95971.1,
RC ECO:0000313|Proteomes:UP000019423};
RA Jung J.-H., Jeong S.-W., Joe M.-H., Cho y.-j., Kim M.-K., Lim S.-Y.;
RT "Complete genome sequence of ionizing-radiation resistance bacterium
RT Hymenobacter swuensis DY53.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CP007145; AHJ95971.1; -; Genomic_DNA.
DR RefSeq; WP_044000817.1; NZ_CP007145.1.
DR AlphaFoldDB; W8F091; -.
DR STRING; 1227739.Hsw_0376; -.
DR KEGG; hsw:Hsw_0376; -.
DR PATRIC; fig|1227739.3.peg.643; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_10; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000019423; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:AHJ95971.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019423}.
FT DOMAIN 7..205
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..307
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 802 AA; 87690 MW; 5F39855ADA0F4D40 CRC64;
MNRTIKKVAV LGSGVMGSRI ACHFANIGVQ VLLLDIAPKE LLPAEEAKGL KLDNPAVKNR
IVNASLQAAV AANPSPLYRK QDVSRIKTGN FDDNLKDIAG CDWTIEVVVE RLDIKKGLFE
RVEQFRKPGT LITSNTSGIP IHMMTEGRSD DFRKHFCGTH FFNPPRYLKL LEIIPTPETD
KSVVDFLMHY GDLYLGKTTV LAKDTPAFIA NRVGVFAIMD VVQVMSELGL TVEEVDKLTG
PVIGHAKSAT FRTSDVVGLD TMINVANGLA QNLPNDEAKH VFQLPDFIKK MAENKWLGDK
TAQGFYKKVK GAGGKSEIQA LDLNTLEYKP SAKVKFATLE ATKPIEKLAD RFKVLAAGKD
KAGDFYRKTF AGLFAYVSNR IPEITDSLYK IDDALRAGFG WDLGPFETWD ALGVQKGLEL
AKAEGKTVAP WVEEMVAAGH TAFYKVSEAG VKQFYDIESK SYQAIPGMEN FIILDNLRAT
GKVLWKNAGA SVLDMGDGIL NVEFHSKMNA LGSDVIQGLL KGVELAEKDF RGLVVGNDAP
NFSAGANLGL VYMFALDQEY DELNLMIAQF QQAMMRMRYS SIPVVGAPHG LALGGGCELN
LHCDRVVAAA ETYMGLVEFG VGLIPGGGGT KEMTLRTALK YEEGEPEYNL LRNAFMTVST
AKVSTSAHEA FDLGFLRRGD EVVVNSNRVL AQAKAAAIEL AEDGYTQPLQ KTNIKVQGKG
ALGMFLTGVH AMKEGRYISD HDVKIANKLA YIMCGGDLSS PTEVSEQYLL DLEREAFLSL
TGERKTLERI QSILTTGKPL RN
//
