ID W8FCD2_9BACT Unreviewed; 934 AA.
AC W8FCD2;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=Hsw_3755 {ECO:0000313|EMBL:AHJ99350.1};
OS Hymenobacter swuensis DY53.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Hymenobacter.
OX NCBI_TaxID=1227739 {ECO:0000313|EMBL:AHJ99350.1, ECO:0000313|Proteomes:UP000019423};
RN [1] {ECO:0000313|EMBL:AHJ99350.1, ECO:0000313|Proteomes:UP000019423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DY53 {ECO:0000313|EMBL:AHJ99350.1,
RC ECO:0000313|Proteomes:UP000019423};
RA Jung J.-H., Jeong S.-W., Joe M.-H., Cho y.-j., Kim M.-K., Lim S.-Y.;
RT "Complete genome sequence of ionizing-radiation resistance bacterium
RT Hymenobacter swuensis DY53.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP007145; AHJ99350.1; -; Genomic_DNA.
DR AlphaFoldDB; W8FCD2; -.
DR STRING; 1227739.Hsw_3755; -.
DR KEGG; hsw:Hsw_3755; -.
DR PATRIC; fig|1227739.3.peg.3912; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000019423; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000019423}.
FT DOMAIN 710..726
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 636..643
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 934 AA; 103811 MW; AB2A6D9B50148AB7 CRC64;
MRTKAADPNK KPIRTHGTLG PAPVVDTPLM RQYYELKQAH PGAVLLFRVG DFYETFGEDA
VTASRILDIT LTKRGAGTAS ETPLAGFPHH SLDTYLPKLV RAGQRVAICD QLEDPKLAKG
LVKRGITELV TPGVSLHDNV LERRSNNYLC AVHFGKHEAG VSFLDISTGE FLVAQGTIDY
LGKLLQNFQP AEVLFCKKSR REFEDHFGPD YCHFALEEWV FGHDYGHDLL TRHFNTTSLK
GFGIDGLREG ITAAGCILHY LAETKHTDVG HIGSIGRLEE DKYVWLDRFT VRNLELVQAQ
HPGGVPLIDI LDQTVTPMGA RLLRKWVVLP LKEPAQIQRR LDTVEALLQT PELLENLLLH
LRQINDLERL ISKVAVRRIN PRELLQLARA LEAISPIREQ LAASGIRALQ KLADQLNPCT
ALREEIRAKI KEDAPILTNQ GGVLNDKVDA ELDELRAMAF SGKDYLFQLQ QRAIQETGIS
SLKVAYNKVF GYYLEVTNSH KDKVPTTWIR KQTLVNAERY ITEELKTYEE KILHAEERLF
VIEQRIYNEL VLTAAEYVAQ VQQNARAIGV ADCLASFAAT ARQHRYVKPV VDDSTLLDIK
AGRHPVIERQ LPPGEQYIPN DICLNQDDQQ IVVITGPNMA GKSALLRQTA LIVLLAQIGS
FVPADAAHVG VIDKIFTRVG ASDNLSKGES TFMVEMTETA SILNNLSDRS LVLMDEIGRG
TSTYDGISIA WAIVEHLHNN PRFTAKTLFA THYHELNQLA DDCPRVRNYN VAVKEADGRI
LFLRKLREGG SEHSFGIHVA RMAGMPTSVV LRANEIMHHL EQERTSTTAE ADQPTEFDEV
LADLDAEPTG GKVVPLNGHP AAAAPEPARR GPKAQPAAAV HNAPRPSLQL SMFEPADPAL
EKVRELLERL DVNTLTPIEA LLKLNELKLA VGGK
//
