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Database: UniProt
Entry: W8HWJ0_ENSAD
LinkDB: W8HWJ0_ENSAD
Original site: W8HWJ0_ENSAD 
ID   W8HWJ0_ENSAD            Unreviewed;       427 AA.
AC   W8HWJ0;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   05-JUN-2019, entry version 27.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   Name=bkdB {ECO:0000313|EMBL:AHK42522.1};
GN   ORFNames=OV14_0460 {ECO:0000313|EMBL:AHK42522.1};
OS   Ensifer adhaerens OV14.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Ensifer.
OX   NCBI_TaxID=1416753 {ECO:0000313|EMBL:AHK42522.1, ECO:0000313|Proteomes:UP000065540};
RN   [1] {ECO:0000313|EMBL:AHK42522.1, ECO:0000313|Proteomes:UP000065540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OV14 {ECO:0000313|EMBL:AHK42522.1,
RC   ECO:0000313|Proteomes:UP000065540};
RX   PubMed=24708309; DOI=10.1186/1471-2164-15-268;
RA   Rudder S., Doohan F., Creevey C.J., Wendt T., Mullins E.;
RT   "Genome sequence of Ensifer adhaerens OV14 provides insights into its
RT   ability as a novel vector for the genetic transformation of plant
RT   genomes.";
RL   BMC Genomics 15:268-268(2014).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP007236; AHK42522.1; -; Genomic_DNA.
DR   RefSeq; WP_025424946.1; NZ_CP007236.1.
DR   EnsemblBacteria; AHK42522; AHK42522; OV14_0460.
DR   KEGG; ead:OV14_0460; -.
DR   PATRIC; fig|1416753.3.peg.453; -.
DR   KO; K09699; -.
DR   Proteomes; UP000065540; Chromosome 1 sequence.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   Gene3D; 4.10.320.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF47005; SSF47005; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS00189; LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:AHK42522.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000065540};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423, ECO:0000256|SAAS:SAAS00065550};
KW   Reference proteome {ECO:0000313|Proteomes:UP000065540};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:AHK42522.1}.
FT   DOMAIN        3     78       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN      141    178       Peripheral subunit-binding (PSBD).
FT                                {ECO:0000259|PROSITE:PS51826}.
FT   REGION       87    131       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W8HWJ0}.
FT   COMPBIAS     89    103       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                W8HWJ0}.
SQ   SEQUENCE   427 AA;  45631 MW;  C5B2585CBCEF3ED9 CRC64;
     MGEFVIKMPD VGEGVAEAEL VEWHVKPGDP VREDMILAAV MTDKATVEIP SPVNGTVLWL
     GAEIGDTVAV KAPLVRIEIA GEGTEALAAE EKPAAKAEEK PVPKTEAPAA TPSQPAKVEA
     KTAAPAKNGV HVSSERLEKA LASPAVRLRA RESGVDLRQV TGTGPAGRIT HDDLDQFLAR
     GAQPVAVPAG LVRKTAIDEI KVTGLRRRIA EKMTLSTSRI PHITYVEEVD MTALEDLRTM
     MNRDRKPDQP KLTILPYLMR ALVRAIADLP GVNSTFDDGA GIINRHHAVH IGIATQTPAG
     LTVPVVRHAE ARGIWDCAVE LNRLAEAART GTATRDELTG STITISSLGA LGGIVTTPVI
     NHPEVAIVGV NKLAVRPVWD GAQFVPRKIM NLSSSFDHRV IDGWDAATFV QRLKALLETP
     ALIFVEA
//
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