ID W8QRH5_9VIRU Unreviewed; 298 AA.
AC W8QRH5;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=AMIV_099 {ECO:0000313|EMBL:AHL67592.1};
OS Anopheles minimus iridovirus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX NCBI_TaxID=1465751 {ECO:0000313|EMBL:AHL67592.1, ECO:0000313|Proteomes:UP000110868};
RN [1] {ECO:0000313|EMBL:AHL67592.1, ECO:0000313|Proteomes:UP000110868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AMIV {ECO:0000313|EMBL:AHL67592.1};
RA Tong Y., Zhang J., Huang Y., Li S., Pei G., Zhang Z., Mi Z., An X.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KF938901; AHL67592.1; -; Genomic_DNA.
DR RefSeq; YP_009021176.1; NC_023848.1.
DR GeneID; 18938260; -.
DR KEGG; vg:18938260; -.
DR OrthoDB; 13491at10239; -.
DR Proteomes; UP000110868; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000110868};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..298
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 298 AA; 34183 MW; 17F7530B48D00824 CRC64;
MGEQAYLKLV EECISDGDYR IDRTKVGTYS LFGKQLEFNL EGGTLPLLTT KKMFVKGILK
ELLWIMKGQT NSKILDKNGV KFWNDNSTRQ FLDSRGLHNY EEGDLGPIYG FQWRFGGKEY
PGQRPLCDCS KGSKGIDQLR EVVEQLKTNP SSRRMIICSW NVAQLNQMAL PPCHCLVQFY
VRNNTHLDCQ LYQRSADIGL GVPFNIASYS FLMYVLAKWT NLTPGRFIHT FGDVHVYSTH
VEALREQIAR QPHSFPTVEF TGEFSLEDLE NVTPEEWCDS FVIRGYKSHP IINMPMAV
//
