ID W8THF8_PEPAC Unreviewed; 341 AA.
AC W8THF8;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative integrase/recombinase y4rC {ECO:0000313|EMBL:AHM57258.1};
GN ORFNames=EAL2_c19770 {ECO:0000313|EMBL:AHM57258.1};
OS Peptoclostridium acidaminophilum DSM 3953.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Peptoclostridium.
OX NCBI_TaxID=1286171 {ECO:0000313|EMBL:AHM57258.1, ECO:0000313|Proteomes:UP000019591};
RN [1] {ECO:0000313|EMBL:AHM57258.1, ECO:0000313|Proteomes:UP000019591}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3953 {ECO:0000313|EMBL:AHM57258.1,
RC ECO:0000313|Proteomes:UP000019591};
RX PubMed=24926057;
RA Poehlein A., Andreesen J.R., Daniel R.;
RT "Complete Genome Sequence of Amino Acid-Utilizing Eubacterium
RT acidaminophilum al-2 (DSM 3953).";
RL Genome Announc. 2:e00573-14(2014).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules.
CC {ECO:0000256|ARBA:ARBA00003283}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
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DR EMBL; CP007452; AHM57258.1; -; Genomic_DNA.
DR RefSeq; WP_025436202.1; NZ_CP007452.1.
DR AlphaFoldDB; W8THF8; -.
DR STRING; 1286171.EAL2_c19770; -.
DR KEGG; eac:EAL2_c19770; -.
DR PATRIC; fig|1286171.3.peg.1924; -.
DR eggNOG; COG4974; Bacteria.
DR HOGENOM; CLU_027562_9_1_9; -.
DR OrthoDB; 9801717at2; -.
DR Proteomes; UP000019591; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR CDD; cd01182; INT_RitC_C_like; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR PANTHER; PTHR30349:SF87; PROPHAGE INTEGRASE INTD-RELATED; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF47823; lambda integrase-like, N-terminal domain; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000019591}.
FT DOMAIN 1..97
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 121..310
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 341 AA; 38198 MW; 460D018C82C8DCB1 CRC64;
MKPSDFAYAL TKYLSAYLPG QCNASENTVR AYRDTFKLLL RFADTQEGIR LERLTLADVD
KSFVEGFLSW LETVQGNAVS TRNHRLAGIH AFFRYLQSEK PDMMLQCQQV LSIPVKRTVK
PTVNYLTVDA VKTILSMPNT STVYGMRDLA LLGLLYDTGA RVSELIELRP KDLRLAAPPV
VTLFGKGRKA RQCPLSSEMT DHLVKYLSAW GLDAPEKSDH PLFVGHNAEK LTRAGVAYVL
SKYVSVAREK NASIIPTIVS PHMLRHSKAM HLLQAGVNLV YIRDWLGHAS IKTTEIYARA
DSEMKRTALQ KAAATVMPQQ SQQSPWAEDV ELMKWLSSLG K
//
