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Database: UniProt
Entry: W8UU58
LinkDB: W8UU58
Original site: W8UU58 
ID   W8UU58_STAAU            Unreviewed;       199 AA.
AC   W8UU58;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   10-APR-2019, entry version 56.
DE   RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN   Name=sodA {ECO:0000313|EMBL:CRI17633.1};
GN   Synonyms=sodM {ECO:0000313|EMBL:CXN34582.1};
GN   ORFNames=BN1321_40056 {ECO:0000313|EMBL:CRI17633.1}, BTN44_00625
GN   {ECO:0000313|EMBL:AUS73846.1}, CSC83_08500
GN   {ECO:0000313|EMBL:PPJ93921.1}, CV021_03995
GN   {ECO:0000313|EMBL:PPJ75746.1}, ELQ85_04630
GN   {ECO:0000313|EMBL:RUQ56626.1}, EP54_06740
GN   {ECO:0000313|EMBL:KMR57345.1}, EQ90_09180
GN   {ECO:0000313|EMBL:KMR36255.1}, ERS072840_00559
GN   {ECO:0000313|EMBL:CXN34582.1}, HMPREF3211_00238
GN   {ECO:0000313|EMBL:KXA40142.1}, M1K003_0636
GN   {ECO:0000313|EMBL:GBV19663.1}, NCTC10654_00163
GN   {ECO:0000313|EMBL:SUL22285.1}, NCTC10702_00282
GN   {ECO:0000313|EMBL:SUL30559.1}, NCTC13131_06218
GN   {ECO:0000313|EMBL:SQA19867.1}, NCTC13196_01115
GN   {ECO:0000313|EMBL:SQB17772.1}, NCTC5664_00801
GN   {ECO:0000313|EMBL:SUK38051.1}, RK64_01130
GN   {ECO:0000313|EMBL:AVG62858.1}, SAMEA1466939_02412
GN   {ECO:0000313|EMBL:SRB81991.1}, SAMEA1708674_03236
GN   {ECO:0000313|EMBL:SCT50741.1};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:CRI17633.1, ECO:0000313|Proteomes:UP000039437};
RN   [1] {ECO:0000313|EMBL:KMR36255.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA15 {ECO:0000313|EMBL:KMR36255.1}, and M121
RC   {ECO:0000313|EMBL:KMR57345.1};
RX   PubMed=26048971; DOI=10.1093/infdis/jiv320;
RA   Planet P.J., Diaz L., Kolokotronis S.O., Narechania A., Reyes J.,
RA   Xing G., Rincon S., Smith H., Panesso D., Ryan C., Smith D.P.,
RA   Guzman M., Zurita J., Sebra R., Deikus G., Nolan R.L., Tenover F.C.,
RA   Weinstock G.M., Robinson D.A., Arias C.A.;
RT   "Parallel Epidemics of Community-Associated Methicillin-Resistant
RT   Staphylococcus aureus USA300 Infection in North and South America.";
RL   J. Infect. Dis. 212:1874-1882(2015).
RN   [2] {ECO:0000313|EMBL:CRI17633.1, ECO:0000313|Proteomes:UP000039437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AH1 {ECO:0000313|EMBL:CRI17633.1,
RC   ECO:0000313|Proteomes:UP000039437};
RA   Syromyatnikov M.Y., Popov V.N.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KXA40142.1, ECO:0000313|Proteomes:UP000070177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PSS7673 {ECO:0000313|EMBL:KXA40142.1,
RC   ECO:0000313|Proteomes:UP000070177};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CXN34582.1, ECO:0000313|Proteomes:UP000069800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=St308 {ECO:0000313|EMBL:CXN34582.1}, and st308
RC   {ECO:0000313|Proteomes:UP000069800};
RG   Pathogen Informatics;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:SCT50741.1, ECO:0000313|Proteomes:UP000249308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GKP138-72 {ECO:0000313|EMBL:SCT50741.1,
RC   ECO:0000313|Proteomes:UP000249308};
RG   Pathogen Informatics;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AUS73846.1, ECO:0000313|Proteomes:UP000236484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA107 {ECO:0000313|EMBL:AUS73846.1,
RC   ECO:0000313|Proteomes:UP000236484};
RA   Bian X., Wang M., Sun H., Fu J., Yu F., Dai L., Liu B., Shi J.;
RT   "Clinical isolated MRSA107 genomics characteristics of resistance to
RT   disinfectants.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:GBV19663.1, ECO:0000313|Proteomes:UP000265645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M1K003 {ECO:0000313|EMBL:GBV19663.1,
RC   ECO:0000313|Proteomes:UP000265645};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y.,
RA   Kusuya Y., Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N.,
RA   Yamaide F., Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G.,
RA   Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of
RT   Staphylococcus quorum-sensing agr mutations in the skin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000213|PDB:6EX4, ECO:0000213|PDB:6EX5}
RP   X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 2-199.
RA   Barwinska-Sendra A., Garcia Y.M., Basle A., Tarrant E., Sendra K.,
RA   Un S., Kehl-Fie T.E., Waldron K.J.;
RT   "An evolutionary path to altered cofactor specificity in a
RT   metalloenzyme.";
RL   Submitted (NOV-2017) to the PDB data bank.
RN   [9] {ECO:0000313|EMBL:PPJ75746.1, ECO:0000313|Proteomes:UP000238775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G703N2B1 {ECO:0000313|EMBL:PPJ75746.1,
RC   ECO:0000313|Proteomes:UP000238775};
RA   Han C.G.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:PPJ93921.1, ECO:0000313|Proteomes:UP000239144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PN235B0 {ECO:0000313|EMBL:PPJ93921.1,
RC   ECO:0000313|Proteomes:UP000239144};
RX   PubMed=29479347; DOI=10.3389/fmicb.2018.00188;
RA   Founou L.L., Founou R.C., Allam M., Ismail A., Djoko C.F.,
RA   Essack S.Y.;
RT   "Genome Sequencing of Extended-Spectrum ?-Lactamase (ESBL)-Producing
RT   Klebsiella pneumoniae Isolated from Pigs and Abattoir Workers in
RT   Cameroon.";
RL   Front. Microbiol. 9:188-188(2018).
RN   [11] {ECO:0000313|EMBL:AVG62858.1, ECO:0000313|Proteomes:UP000035281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FDAARGOS_6 {ECO:0000313|EMBL:AVG62858.1}, and NRS106
RC   {ECO:0000313|Proteomes:UP000035281};
RA   Sichtig H., Tallon L., Sadzewicz L., Sengamalay N., Nagaraj S.,
RA   Vavikolanu K., Aluvathingal J., Nadendla S., Pirone D.C., Hoffman M.,
RA   Muruvanda T., Allard M., Evans P.;
RT   "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT   Supporting development and validation of Infectious Disease Dx
RT   tests.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|Proteomes:UP000250033, ECO:0000313|Proteomes:UP000250259, ECO:0000313|Proteomes:UP000251686}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EOE009 {ECO:0000313|EMBL:SRB81991.1,
RC   ECO:0000313|Proteomes:UP000250259}, NCTC10654
RC   {ECO:0000313|EMBL:SUL22285.1, ECO:0000313|Proteomes:UP000255075},
RC   NCTC10702 {ECO:0000313|EMBL:SUL30559.1}, NCTC13131
RC   {ECO:0000313|EMBL:SQA19867.1, ECO:0000313|Proteomes:UP000251686},
RC   NCTC13196 {ECO:0000313|EMBL:SQB17772.1,
RC   ECO:0000313|Proteomes:UP000250033}, and NCTC5664
RC   {ECO:0000313|EMBL:SUK38051.1};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:RUQ56626.1, ECO:0000313|Proteomes:UP000275970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZS_Z46 {ECO:0000313|EMBL:RUQ56626.1,
RC   ECO:0000313|Proteomes:UP000275970};
RA   Suhaili Z., Yeo C.C., Badaluddin N.A., Ghazali M.F., Amin Nordin S.,
RA   Mohd Desa M.N.;
RT   "Draft genome sequence of Staphylococcus aureus strain ZS_Z46 MRSA
RT   SCCmec III-ST239 from community nasal swab in Terengganu, Malaysia.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000414}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000414};
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000256|RuleBase:RU000414}.
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DR   EMBL; CP018629; AUS73846.1; -; Genomic_DNA.
DR   EMBL; CP026962; AVG62858.1; -; Genomic_DNA.
DR   EMBL; CVOQ01000034; CRI17633.1; -; Genomic_DNA.
DR   EMBL; FGEC01000003; CXN34582.1; -; Genomic_DNA.
DR   EMBL; BDVT01000002; GBV19663.1; -; Genomic_DNA.
DR   EMBL; LALJ01000018; KMR36255.1; -; Genomic_DNA.
DR   EMBL; LALQ01000022; KMR57345.1; -; Genomic_DNA.
DR   EMBL; LRQH01000023; KXA40142.1; -; Genomic_DNA.
DR   EMBL; PGWZ01000323; PPJ75746.1; -; Genomic_DNA.
DR   EMBL; PDUY01000105; PPJ93921.1; -; Genomic_DNA.
DR   EMBL; RZHK01000002; RUQ56626.1; -; Genomic_DNA.
DR   EMBL; FMPP01000023; SCT50741.1; -; Genomic_DNA.
DR   EMBL; UAUZ01000006; SQA19867.1; -; Genomic_DNA.
DR   EMBL; UAVX01000005; SQB17772.1; -; Genomic_DNA.
DR   EMBL; UDIX01000020; SRB81991.1; -; Genomic_DNA.
DR   EMBL; UHAQ01000002; SUK38051.1; -; Genomic_DNA.
DR   EMBL; UHBX01000004; SUL22285.1; -; Genomic_DNA.
DR   EMBL; UHBY01000003; SUL30559.1; -; Genomic_DNA.
DR   RefSeq; WP_000874681.1; NZ_UIOA01000017.1.
DR   PDB; 6EX4; X-ray; 2.40 A; A/B=1-199.
DR   PDB; 6EX5; X-ray; 1.75 A; A/B=2-199.
DR   EnsemblBacteria; AOO97366; AOO97366; FORC27_0128.
DR   EnsemblBacteria; CFG01556; CFG01556; ERS093009_00846.
DR   EnsemblBacteria; CRI17633; CRI17633; BN1321_40056.
DR   EnsemblBacteria; CXE43976; CXE43976; ERS074020_00889.
DR   EnsemblBacteria; CXL82808; CXL82808; ERS072738_00830.
DR   EnsemblBacteria; CXN34582; CXN34582; ERS072840_00559.
DR   EnsemblBacteria; CXT61896; CXT61896; ERS073147_02394.
DR   EnsemblBacteria; CYD47861; CYD47861; ERS073767_02269.
DR   EnsemblBacteria; CZQ27574; CZQ27574; ERS1058648_00955.
DR   EnsemblBacteria; KXA40142; KXA40142; HMPREF3211_00238.
DR   EnsemblBacteria; OAP75757; OAP75757; A4U86_04870.
DR   EnsemblBacteria; SCR67196; SCR67196; SAMEA2298760_02426.
DR   KEGG; saud:CH52_05060; -.
DR   KEGG; saur:SABB_01708; -.
DR   PATRIC; fig|1280.10341.peg.129; -.
DR   KO; K04564; -.
DR   BioCyc; GCF_001546605-HMP:HMPREF3211_RS01240-MONOMER; -.
DR   Proteomes; UP000035281; Chromosome.
DR   Proteomes; UP000039437; Unassembled WGS sequence.
DR   Proteomes; UP000069800; Unassembled WGS sequence.
DR   Proteomes; UP000070177; Unassembled WGS sequence.
DR   Proteomes; UP000236484; Chromosome.
DR   Proteomes; UP000238775; Unassembled WGS sequence.
DR   Proteomes; UP000239144; Unassembled WGS sequence.
DR   Proteomes; UP000249308; Unassembled WGS sequence.
DR   Proteomes; UP000250033; Unassembled WGS sequence.
DR   Proteomes; UP000250259; Unassembled WGS sequence.
DR   Proteomes; UP000251686; Unassembled WGS sequence.
DR   Proteomes; UP000255075; Unassembled WGS sequence.
DR   Proteomes; UP000265645; Unassembled WGS sequence.
DR   Proteomes; UP000275970; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   Gene3D; 2.40.500.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019833; Mn/Fe_SOD_BS.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   PRINTS; PR01703; MNSODISMTASE.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
DR   PROSITE; PS00088; SOD_MN; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:6EX4, ECO:0000213|PDB:6EX5};
KW   Complete proteome {ECO:0000313|Proteomes:UP000035281,
KW   ECO:0000313|Proteomes:UP000039437, ECO:0000313|Proteomes:UP000069800,
KW   ECO:0000313|Proteomes:UP000070177};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW   ECO:0000256|RuleBase:RU000414};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000414,
KW   ECO:0000313|EMBL:CRI17633.1}.
FT   DOMAIN        3     89       Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT   DOMAIN       96    193       Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT   METAL        27     27       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL        81     81       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       161    161       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
FT   METAL       165    165       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000349-1}.
SQ   SEQUENCE   199 AA;  23041 MW;  388566FB9943C635 CRC64;
     MAFKLPNLPY AYDALEPYID QRTMEFHHDK HHNTYVTKLN ATVEGTELEH QSLADMIANL
     DKVPEAMRMS VRNNGGGHFN HSLFWEILSP NSEEKGGVID DIKAQWGTLD EFKNEFANKA
     TTLFGSGWTW LVVNDGKLEI VTTPNQDNPL TEGKTPILLF DVWEHAYYLK YQNKRPDYMT
     AFWNIVNWKK VDELYQAAK
//
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