ID W9AQI7_9BACI Unreviewed; 565 AA.
AC W9AQI7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA polymerase III subunit gamma/tau {ECO:0000256|RuleBase:RU364063};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU364063};
GN Name=dnaX_1 {ECO:0000313|EMBL:CDO04886.1};
GN Synonyms=dnaX {ECO:0000256|RuleBase:RU364063};
GN ORFNames=BN988_03463 {ECO:0000313|EMBL:CDO04886.1}, OPHB3_2000
GN {ECO:0000313|EMBL:GAQ18061.1};
OS Oceanobacillus picturae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=171693 {ECO:0000313|EMBL:CDO04886.1, ECO:0000313|Proteomes:UP000028863};
RN [1] {ECO:0000313|EMBL:CDO04886.1, ECO:0000313|Proteomes:UP000028863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S1 {ECO:0000313|EMBL:CDO04886.1,
RC ECO:0000313|Proteomes:UP000028863};
RA Croce O., Lagier J.C., Raoult D.;
RT "Draft genome sequencing of Oceanobacillus picturae strain S1 isolated from
RT human gut.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDO04886.1, ECO:0000313|Proteomes:UP000028863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S1 {ECO:0000313|EMBL:CDO04886.1,
RC ECO:0000313|Proteomes:UP000028863};
RA Urmite Genomes U.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000052946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Heshi-B3 {ECO:0000313|Proteomes:UP000052946};
RA Akuzawa S., Nakagawa J., Kanekatsu T., Kanesaki Y., Suzuki T.;
RT "Draft Genome Sequence of Oceanobacillus picturae Heshi-B3 that Was
RT Isolated from Fermented Rice Bran with Aging Salted Mackerel, Which Was
RT Named Heshiko as Traditional Fermented Seafood in Japan.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:GAQ18061.1, ECO:0000313|Proteomes:UP000052946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Heshi-B3 {ECO:0000313|EMBL:GAQ18061.1,
RC ECO:0000313|Proteomes:UP000052946};
RA Akuzawa S., Nagaoka J., Kanekatsu M., Kanesaki Y., Suzuki T.;
RT "Draft Genome Sequence of Oceanobacillus picturae Heshi-B3, Isolated from
RT Fermented Rice Bran in a Traditional Japanese Seafood Dish.";
RL Genome Announc. 4:e01621-15(2016).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity.
CC {ECO:0000256|RuleBase:RU364063}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU364063};
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III
CC complex. {ECO:0000256|RuleBase:RU364063}.
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360, ECO:0000256|RuleBase:RU364063}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDO04886.1}.
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DR EMBL; CCAX010000003; CDO04886.1; -; Genomic_DNA.
DR EMBL; BBXV01000023; GAQ18061.1; -; Genomic_DNA.
DR RefSeq; WP_036578158.1; NZ_CCAX010000003.1.
DR AlphaFoldDB; W9AQI7; -.
DR STRING; 171693.BN988_03463; -.
DR eggNOG; COG2812; Bacteria.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000028863; Unassembled WGS sequence.
DR Proteomes; UP000052946; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364063};
KW DNA replication {ECO:0000256|RuleBase:RU364063};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU364063};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU364063};
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU364063};
KW Reference proteome {ECO:0000313|Proteomes:UP000028863};
KW Transferase {ECO:0000256|RuleBase:RU364063}.
FT DOMAIN 37..179
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 399..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 63109 MW; 5F33D5ABC9CB05CB CRC64;
MSYQALYRVW RPRKFQDVVG QTHITRTLQN AIVQEKFSHA YVFSGPRGTG KTSAAKIFAK
TINCEQAPAK EPCNECAACR GIQDGSISDV IEIDAASNTS VEDIRDIRDK VKYASSSVPY
KVYIIDEVHM ISTNAFNALL KTLEEPPKHV VFILATTEPH KIPLTILSRC QRFDFKPISN
AAIVERMQSI IDAEGISVSQ EAMETVALAA EGGMRDALSI LDQAISYSEE KVELEDVLAV
TGGVSQQILT DMVQSMHEKN VQHALKQLDE LISRGKDPGR FVYDMIYFLR DLLLFKSAPS
LEGLLERART DESFTSLAEA VSIQWVQQAI MELNQCQQEM KWTNSPKVFI EIAVLSLTNG
QQQTDAAPVA ERNEDSDAVM KLTSKLSALE KEVAALKQNP QAAVQTAAPR EQRRPQTRAT
KNSYKIPNER IRDVLKQAEK AALKNVHGQW ANFLSKLKSS NAPAHATIQD SKPVAASDQA
IIVAFKYEIH CSLFLDNRET VESVLASVLN KQLTIIPIPE LNWSEIRTDY INNQEKSNES
EEQQVDPLVE EARKLVGDDL IEIHD
//
