ID W9CMT0_SCLBF Unreviewed; 302 AA.
AC W9CMT0;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN ORFNames=SBOR_3651 {ECO:0000313|EMBL:ESZ95959.1};
OS Sclerotinia borealis (strain F-4128).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=1432307 {ECO:0000313|EMBL:ESZ95959.1, ECO:0000313|Proteomes:UP000019487};
RN [1] {ECO:0000313|EMBL:ESZ95959.1, ECO:0000313|Proteomes:UP000019487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F-4157 {ECO:0000313|Proteomes:UP000019487};
RX PubMed=24459262; DOI=10.1128/genomeA.01175-13;
RA Mardanov A.V., Beletsky A.V., Kadnikov V.V., Ignatov A.N., Ravin N.V.;
RT "Draft genome sequence of Sclerotinia borealis, a psychrophilic plant
RT pathogenic fungus.";
RL Genome Announc. 2:E0117513-E0117513(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESZ95959.1}.
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DR EMBL; AYSA01000159; ESZ95959.1; -; Genomic_DNA.
DR AlphaFoldDB; W9CMT0; -.
DR STRING; 1432307.W9CMT0; -.
DR HOGENOM; CLU_023205_0_1_1; -.
DR OrthoDB; 5305445at2759; -.
DR Proteomes; UP000019487; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019487}.
FT DOMAIN 39..287
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 70
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 134
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 99
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 302 AA; 33627 MW; A3E05700EBD30DD0 CRC64;
MTSQDQVSPP TLELPLAIDS KRYSVIKRIS TVGIPRLGFG VYQSHGQKCI DAVLAALRAG
YRHIDTAQYY ANEKEVGIAI QAFIKESGIK RSDIFITTKI LSPGGSVTLS FAKCFNSIKA
IDGDDGYVDL FLIHSPNSGS DSRKEMYDAL EKLFMLRKVR MIGVSNWGIG HLEELKGFAI
MWPPHVNQIE LHPFCQQRAV VEYCVANGIH VEAYCPLVRN TRSDDPTLNS IATIHMQTVA
QVLIRYALQK DWIPLPKSET PSRIAENANV FDFVLNEEEM QKLDGLDEGD KGAIVQAVTN
EL
//
