ID   W9EHQ4_9LACO            Unreviewed;       530 AA.
AC   W9EHQ4;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=B808_568 {ECO:0000313|EMBL:ETO40515.1};
OS   Fructilactobacillus florum 8D.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Fructilactobacillus.
OX   NCBI_TaxID=1221538 {ECO:0000313|EMBL:ETO40515.1, ECO:0000313|Proteomes:UP000019474};
RN   [1] {ECO:0000313|EMBL:ETO40515.1, ECO:0000313|Proteomes:UP000019474}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=8D {ECO:0000313|EMBL:ETO40515.1,
RC   ECO:0000313|Proteomes:UP000019474};
RA   Kim E.B., Marco M.L.;
RT   "Genome sequencing of Lactobacillus florum 8D.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETO40515.1}.
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DR   EMBL; ALXG01000026; ETO40515.1; -; Genomic_DNA.
DR   RefSeq; WP_009166424.1; NZ_ALXG01000026.1.
DR   AlphaFoldDB; W9EHQ4; -.
DR   PATRIC; fig|1221538.3.peg.571; -.
DR   OrthoDB; 9761056at2; -.
DR   Proteomes; UP000019474; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019474};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        31..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        62..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        129..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        153..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        186..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        216..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        245..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        300..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        344..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        385..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        421..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        512..529
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   530 AA;  56834 MW;  080A4AB2A74BF9F8 CRC64;
     MYLLLSVLPI LLPVFFLGVL NWPAPKGMGI SAVMIMIVGF FFWKMPILAV TASLLQGIHK
     SLPIVWILFG ALLLLRALEF TNSIQRINLG FTRLTTDMRL QAVIVTFLFG SLIEGVSGFG
     TPAMVTAPLL IALGFKPLSA VVLALAADST ASSFGAVGTP LTVGLSNTLS AGGLENVSTK
     ITTVELISGT FLPLILIFLL VVLLPNQQQK NKLGSVLELA PWALLIGFCY NGIGWITQHF
     LGHEMVAIIS SIGALGLAVL TIRLHFLLPA KLEKHPWQQT PQSRELNSAE SVTMPLWLAW
     FPYVLTVILL VLPKFVPAIH HFLTNQVNLS WMKILGFKTI NSEWLLLASP GTVLVLVAIV
     TLLIHRVSWA DFGTETKQVV VSMKYTVLAL VVTLVMVQVF TNSGINTSSL ASMPEFLAEK
     LAHAFSGIWL GIAPLLGGLG SFVTGSTTVS TLTFAPVQAS VAKDAGLDVD LVLALQVIGA
     SIGNMICIHN IVAVSGVVGL TGKEGQVLRE NALPVLFYFG LLLVAIMIVS
//