ID W9GKG7_9MICO Unreviewed; 384 AA.
AC W9GKG7;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EWT05323.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:EWT05323.1};
GN ORFNames=N864_05385 {ECO:0000313|EMBL:EWT05323.1};
OS Intrasporangium chromatireducens Q5-1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Intrasporangium.
OX NCBI_TaxID=584657 {ECO:0000313|EMBL:EWT05323.1, ECO:0000313|Proteomes:UP000019494};
RN [1] {ECO:0000313|Proteomes:UP000019494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Q5-1 {ECO:0000313|Proteomes:UP000019494};
RA Liu H., Wang G.;
RT "Intrasporangium oryzae NRRL B-24470.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWT05323.1}.
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DR EMBL; AWQS01000123; EWT05323.1; -; Genomic_DNA.
DR RefSeq; WP_034717869.1; NZ_AWQS01000123.1.
DR AlphaFoldDB; W9GKG7; -.
DR PATRIC; fig|584657.3.peg.2791; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000019494; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:EWT05323.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019494};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EWT05323.1}.
FT DOMAIN 4..250
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 260..380
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 338
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 368
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 384 AA; 40583 MW; 8D2D675CAF219999 CRC64;
MREVIVAAAL RTPVGVGKPT KGVFSGTHPA DLSAVVLREL LAREDIDPDA VEDVIWGCVA
QVGEQSSNIA RTAALSAGYP VEVPGVTIDR QCGSSQQALH FGAASVAAGH YDVVVVGGVE
SMSRVPMRTH LAGGEGPWSP GFRERFAYVN QGISAEMIAE RWNLSRAWLD ELSVRSHELA
WAATRDGTFQ PETVPVDTDR GRVQQDQGIR PSTTREALAR LRPAFKDDGV ITAGNSSQIS
DGAAALLLTT PDRARQLGLT PLVRVHAVAL AGVHPDIKLT GPIPATEKVL RRAALSINDI
GVFEVNEAFA SVVGAWLKET GADLARVNPR GGAIALGHPL GGSGARIATT LVHEMVREGH
RYGLQTMCEG GGMANATIFE LVAH
//
