ID W9GMQ6_9MICO Unreviewed; 477 AA.
AC W9GMQ6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:EWT07395.1};
GN ORFNames=N864_07870 {ECO:0000313|EMBL:EWT07395.1};
OS Intrasporangium chromatireducens Q5-1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Intrasporangium.
OX NCBI_TaxID=584657 {ECO:0000313|EMBL:EWT07395.1, ECO:0000313|Proteomes:UP000019494};
RN [1] {ECO:0000313|Proteomes:UP000019494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Q5-1 {ECO:0000313|Proteomes:UP000019494};
RA Liu H., Wang G.;
RT "Intrasporangium oryzae NRRL B-24470.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785, ECO:0000256|RuleBase:RU003427}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EWT07395.1}.
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DR EMBL; AWQS01000013; EWT07395.1; -; Genomic_DNA.
DR RefSeq; WP_034713431.1; NZ_AWQS01000013.1.
DR AlphaFoldDB; W9GMQ6; -.
DR PATRIC; fig|584657.3.peg.651; -.
DR OrthoDB; 9805787at2; -.
DR Proteomes; UP000019494; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 2.
DR Pfam; PF03949; Malic_M; 1.
DR PRINTS; PR00072; MALOXRDTASE.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU003427};
KW Reference proteome {ECO:0000313|Proteomes:UP000019494}.
FT DOMAIN 99..232
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 244..466
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 477 AA; 50844 MW; 8D804CE57C66F035 CRC64;
MTESIQRAKA TTASYSITVR IHAGTDPAVI GQLAIKVADS GGITTALDIV DSHPDRLVID
LTCSASDADH AAEIVEAIET LDGVRVHKVS DRTFLLHLGG KISVESKVNL RNRQDLAMAY
TPGVGRVSMA LYEHPEDVPR LTIKGNSVAV VTDGTAVLGL GNIGPQAALP VMEGKAALFK
RFADIDAWPI CLDTTDADEI VRAVELIAPG FGGINLEDIA APKCFEIEAK LRERLDIPVF
HDDQHGTAIV VLAALTNALR VIDKPLPEAR ILVSGGGAAG SAIVQLLLAA GAVDVTVFDR
PGLLNKDDES LTPAWRQLAE RTNPRGLRGT LRDGIQGADV FIGVSAPRIL KPEWIDEMAP
ERVVFALANP DPEVDIFEAT QRATVVASGR SDYPNQINNV LAFPGVFRGL LDARATDVTT
EMLIKAAEAI ASVVTDEQLN PNYIIPSVFH PDMSKTVAKA IVDCVPKAPE PSIPMTQ
//
